Industrial Production of Bioproducts
Code: 45022 ECTS Credits: 9| Degree | Type | Year | Semester |
|---|---|---|---|
| 4314579 Biological and Environmental Engineering | OB | 1 | 1 |
Contact
- Name:
- Oscar Enrique Romero Ormazabal
- Email:
- oscarenrique.romero@uab.cat
Teaching groups languages
You can check it through this link. To consult the language you will need to enter the CODE of the subject. Please note that this information is provisional until 30 November 2023.
Teachers
- Francesc Gòdia Casablancas
- José Luis Montesinos Seguí
- Francisco Valero Barranco
- Albert Sales Vallverdú
- Laura Cervera Gracia
Prerequisites
To attend the module it is necessary to have a basic formation in Biochemical Engineering, in fundamental aspects of Bioprocess Engineering, in Bioreactors and some very basic concepts of recombinant DNA and Genetic Engineering.
Objectives and Contextualisation
The objective of this module is to familiarize the student with the most important tools used in a bioprocess, and its application in the design and operation of bioprocesses in their future professional careers. In order to achieve this objective, different cellular factories will be explored, designed, integrated and optimized for producing industrial biotechnological products, integrating the production and purification of the bioproduct in a reproducible way (BIOPAT concept) and economically viable Bioprocess Engineering. The quality and safety regulations of bioproducts from different fields will also be explained and the principles on which the scale up of a bioprocess is based will be presented.
Learning Outcomes
- CA06 (Competence) Integrate and justify the use of different biotechnology and bioprocess engineering instruments to solve emerging problems in fields of industrial biotechnology.
- CA07 (Competence) Integrate knowledge and deal with the complexity of formulating judgments based on information that, due to being incomplete or limited, requires consideration of the social and ethical responsibilities associated to the application of one's knowledge and judgements.
- CA07 (Competence) Integrate knowledge and deal with the complexity of formulating judgments based on information that, due to being incomplete or limited, requires consideration of the social and ethical responsibilities associated to the application of one's knowledge and judgements.
- CA08 (Competence) Integrate and abridge the information obtained from the scientific literature using the appropriate channels, contrasting and critically debating different alternatives.
- KA05 (Knowledge) Contrast the advantages, disadvantages and the bioprocess engineering required for prokaryotic E.coli cell factories, eukaryotic P.pastoris cell factories and animal cell factories.
- SA01 (Skill) Search, compare, critically analyse and summarise information obtained from databases and other sources to solve complex problems in one's specialist area.
- SA02 (Skill) Prepare technical reports in the field of environmental engineering and/or biological engineering and present the results orally in a clear, concise and unambiguous manner.
- SA03 (Skill) Plan the different activities related to the resolution of tasks assigned as part of a work group, while appropriately managing time and resources.
- SA03 (Skill) Plan the different activities related to the resolution of tasks assigned as part of a work group, while appropriately managing time and resources.
- SA05 (Skill) Assess problems with scale-up and scale-down in Biotechnology.
Content
1.- Introduction to the industrial production of bioproducts. Scale up in bioreactors
2.- Bioprocess design based on quality.
2.1.- Quality by Design (QbD) / Process Analytical Technology (PAT)
2.2.-Good Manufacturing Practice (GMPs). Good Laboratory Practices (BPLs),
3.-Cell factories: Animal cell culture
4.-Cell factories: Pichia pastoris.
5.-Cell factories: Escherichia coli.
6.- Case of study workshop
Methodology
Lectures on the topics of the syllabus.
Seminars on aspects of the industrial world of Biotechnology by experts invited from the sector.
Elaboration of gruop works. Group activity. Students will prepare a report on a topic related to the contents, at the teacher's proposal. These works will be exposed and defended in public.
Case study workshop. Students will carry out workshops on the different cell factories, consisting offamiliarization with a recombinant protein production process, cell cultures and bioprocess monitoring.
Annotation: Within the schedule set by the centre or degree programme, 15 minutes of one class will be reserved for students to evaluate their lecturers and their courses or modules through questionnaires.
Activities
| Title | Hours | ECTS | Learning Outcomes |
|---|---|---|---|
| Type: Directed | |||
| Case study workshop | 20 | 0.8 | CA06, CA07, CA08, KA05, SA01, SA02, SA03, CA06 |
| Lectures | 33.5 | 1.34 | CA06, CA07, CA08, KA05, SA01, SA02, SA03, SA05, CA06 |
| Seminars | 4 | 0.16 | CA06, CA07, SA05, CA06 |
| Type: Supervised | |||
| Group work | 35 | 1.4 | CA06, CA08, KA05, SA01, SA02, SA03, SA05, CA06 |
| Workshop report | 15 | 0.6 | CA06, CA08, KA05, SA01, SA02, SA03, SA05, CA06 |
| Type: Autonomous | |||
| Case study preparation | 10 | 0.4 | CA06, CA07, KA05, SA01, SA02, SA03, CA06 |
| Preparation of writing work and oral exposure | 24.5 | 0.98 | CA06, CA07, CA08, KA05, SA01, SA02, SA03, CA06 |
| Search of documentation and bibliography | 28 | 1.12 | CA06, CA07, CA08, KA05, SA01, CA06 |
| Study | 50 | 2 | CA06, CA07, KA05, SA03, CA06 |
Assessment
Evaluation of the theoretical part of the module:
Continuous assessment
Individual written evaluation: It is 70% of the final grade. Four partial tests corresponding to different subjects of the course are carried out with a weight of 25% each of them. If in the individual written evaluation the student obtained a grade lower than 3/10, he will not pass the module.
Evaluation of the defense and oral presentation of a research paper (30%)
Final evaluation:
Students who do not pass the continuous assessment will have a global test of written individual final recovery. Whenever this test is exceeded with a grade higher than 3/10, it will be done with the grade of the oral presentation.
Global evaluation of the module
Evaluation of workshop (25%).
Evaluation of the theoretical part of the module (75%). Minimum note of this part to approve the module 3.5/10.
Single assessment: There is no single assessment in this subject.
The calendar of exams and the different activities to be carried out in the module will be announced at the beginning of the course. Once scheduled, in no case will exams be held with different dates and times.
For the review of the results of the evaluations, the time and manner will be fixed within 10 working days after the communication of the results through the virtual platform. If the student does not show up for this review, this activity will not be subsequently reviewed.
Matriculation of Honor (MH). Awarding the grade of MH is the decision of the faculty responsible for the subject. UAB regulations state that MHs can only be awarded to students who obtain a final grade equal to or higher than 9.00. Up to 5% of the total number of students may be awarded MHs.
A student is considered as not evaluable (NA) if he/she has not shown up for any of the evaluation activities.
Regardless of other disciplinary measures that may be considered appropriate, irregularities committed by students that may result in a modification of the grade of an evaluation activity will be graded with a zero. Therefore, copying, plagiarism, cheating, allowing copying, etc... in any of the evaluation activities will imply a zero grade.
Assessment Activities
| Title | Weighting | Hours | ECTS | Learning Outcomes |
|---|---|---|---|---|
| 4 Writing exams | 13,1% each one | 3 | 0.12 | CA06, CA07, CA08, KA05, SA01, SA02, SA03, SA05 |
| Assesment of workshop | 25% | 1 | 0.04 | CA06, CA07, CA08, KA05, SA02, SA03, SA05 |
| Assessment of oral presentation | 22,5% | 1 | 0.04 | CA06, CA07, CA08, SA01, SA02, SA03 |
Bibliography
The bibliography needed to follow the module can be consulted through the virtual platform. In parallel, the student will have to carry out searches and specific bibliographical consultations for the elaboration of their group work.
Software
It is not planned to use any specific software for the subject.