Degree | Type | Year | Semester |
---|---|---|---|
4311309 Pharmacology | OT | 0 | 1 |
There are no special prerequisites.
To apply basic pharmacological and methodological knowledge to develop preclinical drug research and interpret the results.
a) Evaluation and validation of a pharmacological target. Molecular screening: automation and high performance. Levels of pharmacological research: computer (in silica), cells, organs, animals, humans. In vitro studies: molecular for the evaluation of targets, cell cultures (biochemical and molecular), isolated organs (physiological, biochemical and molecular). Ex vivo studies. Methodologies used in in vivo studies: conscious animal and anesthetized animal (measurement of blood pressure). Animal models of diseases induced by administration of compounds, by surgical intervention or by genetic manipulation. Methodologies for studies of psychotropic drugs.
b) In silico studies. In vitro studies: physical-chemical characterization (release, dissolution). In vitro studies: metabolism. In vivo studies: handling of animals, choice of species. In vivo studies: design. Microdialysis techniques. Plasma protein binding. Animal / human extrapolation (allometry): data analysis. Toxicokinetics and special pharmacokinetics.
c) Mechanisms of toxicity. In vitro toxicity studies. In vivo toxicity studies: single administration. In vivo toxicity studies: repeated administration. Toxic-anatomopathology. Reproductive toxicology: infertility, teratogenicity (embryotoxicity). Genotoxicity Carcinogenesis Phototoxicity Immunotoxicity Local tolerability Behavior tests
d) Ethics of animal research. Ethical committees BPLs: Good Laboratory Practices. Guidelines for pre-clinical research of Regulatory Agencies. Legislation. Preclinical information for registration. Study of patent situation.
e) Models, development strategies / techniques: empirical, mechanistic. Theory of statistical moments. Convolution / deconvolution: theory and applications. Non-linear adjustment. Population approximation. Sensitivity analysis and biases: strategies and applications.
The final grade is the arithmetic mean of the grades obtained in the subjects that compose it.
Annotation: Within the schedule set by the centre or degree programme, 15 minutes of one class will be reserved for students to evaluate their lecturers and their courses or modules through questionnaires.
Title | Hours | ECTS | Learning Outcomes |
---|---|---|---|
Type: Directed | |||
Classroom practices (PAUL) | 11 | 0.44 | 1, 2, 3, 5, 4, 6, 7 |
Clinical case seminars (SCC) | 4 | 0.16 | 1, 2, 3, 5, 4, 6, 7 |
Master Class (TE) | 50 | 2 | 1, 2, 3, 5, 4, 6, 7 |
Practical Experimental Laboratory (PLAB) | 3 | 0.12 | 1, 2, 3, 5, 4, 6, 7 |
Type: Supervised | |||
Review of papers | 24 | 0.96 | 1, 2, 3, 5, 4, 6, 7 |
Unscheduled tutorials | 3 | 0.12 | 1, 2, 3, 5, 4, 6, 7 |
Type: Autonomous | |||
Study, written works ... | 127 | 5.08 | 1, 2, 3, 5, 4, 6, 7 |
The final grade is the arithmetic mean of the grades obtained in the subjects that compose it.
Title | Weighting | Hours | ECTS | Learning Outcomes |
---|---|---|---|---|
Attendance and participation | 10 % | 0 | 0 | 1, 2, 3, 5, 4, 6, 7 |
Oral presentations | 42,5 % | 2 | 0.08 | 1, 2, 3, 5, 4, 6, 7 |
Short questions exam | 47,5 % | 1 | 0.04 | 1, 2, 3, 5, 4, 6, 7 |
Updated bibliography will be provided for ech subject.
General bibliography
- Burton LL, Lazo JS, Parker KL. Goodman & Gilman. Las Bases Farmacológicas de la Terapéutica. 13a Edición. Madrid: McGraw-Hill Interamericana de España S.L., 2018.
- Doménech J, Martínez J, Plá JM. Biofarmacia y Farmacocinética Volumen I: Farmacocinética. Madrid: Editorial Síntesis, 2000.
- Fundación Genoma España. Guia de desarrollos preclínicos. Genoma España. 10 aniversario (2002-2012). https://www.agenciasinc.es/Noticias/Genoma-Espana-publica-una-guia-de-desarrollos-preclinicos
- Kenakin TP. Pharmacology in Drug Discovery and Development. 2nd Edition. London: Academic Press, 2016.
- Lorenzo P, Moreno A, Leza JC, Lizasoain I, Moro MA, Portolés A. Velazquez. Manual de farmacologia basica y clinica. Madrid: Editorial Médica Panamericana, 2021.
- Rosenfeld GC, Loose DS. Pharmacology. 4th Ed. Baltimore: Lippincott Williams & Wilkins, 2006.
- Weisman RS, Smith C, Goldfrank LR. Toxicokinetics. Applying pharmacokinetic principles to the poisoned patient. In: Hoffman RS, Goldfrank LR eds. Critical Care Toxicology (Contemporary management in critical care). New York: Churchill Livingstone, 1991 (vol 1; no 3): 21-42.
- Young-Jin S, Shannon M. Pharmacokinetics of Drugs in Overdose. Clinical Pharmacokinetics 1992; 23 (2): 93-105.
No special software is required.