Degree | Type | Year | Semester |
---|---|---|---|
4313802 Advanced Genetics | OT | 0 | 1 |
There are not special pre-requisites in this module
The objective of this module is to add aknowledgement on the concepts of genetic risk and in the use of biomonitoring data to detect human populations
at risk
Theme 1. Genetic damage
Basic concepts. DNA damage vs mutation. Types of genetic damage. Spontaneous vs induced DNA damage.
Germinal vs somatic mutations. Consequences for human health.
Theme 2. Genetic risk
Definitions. Components. Genetic hazards. Genotoxic potency. Exposure. Genetic risk assessment. Risk
management.
Theme 3. Indirect ways to measure genetic damage
Short-term assays classification. Evaluation strategies. Concept of battery. Organisms and assays used to
estimate the genotoxic potential.
Theme 4. Indirect way to measure exposure
Concepts of exposure. Processes for exposure assessment. Exposure and genetic risk. Sources of exposure.
Theme 5. Human Biomonitoring
Concept of human biomonitoring. Sampling procedures. Use of somatic cells. Use of germinal cells.
Theme 6. Mutation-Cancer relationship
Genotoxic carcinogens. Non-genotoxic carcinogens. Epidemiological data as a source to detect agents with
genotoxic activity
Theme 7. Biomonitoring and primary DNA damage
Methods to estimate primary DNA damage. The comet assay as a model. Oxidative DNA damage. Role of
primary DNA damage in the genetic risk
Theme 8. Biomonitoring and chromosome damage
Methods to estimate chromosome damage. The micronucleus assay as a model. Usefulness of FISH
technologies. Role of chromosome damage in the genetic risk
Theme 9. Biomonitoring and gene mutations
Molecular analysis of somatic mutations: hprt and HLA. Molecular epidemiology and biomarkers of
occupational cancer. Oncogenes and their proteins. The ras gene and the protein p21. The p21 protein as a
biomarkers of cancer.
Theme 10. Biomarkers of individual sensitivity
Biomarkers of interindividual variation. Interindividual variation and genotoxic exposure. Genetic and
no-genetic specificity in cancer. Genomic instability.
Theme 11. Factors modulating the genetic risk
Endogen factors. Basal levels of mutation Other factors. The diet as a modulating factor
Theme 12. Examples of biomonitoring studies
Risk and ionizing radiation. Risk and heavy metals exposure. Risk of pesticide exposures
Unless the requirements enforced by the health authorities demand a prioritization or reduction of these contents.
Lectures will constitute the main part of the course.
For each theme, the student will prepare a written work summarizing one of the papers discussed in the clasroom.
Several topics will be explained as a seminars. To cover this topic, the students will receive material to prepare the theme that will be exposed and discused in the class.
The proposed teaching methodology may experience some modifications depending on the restrictions to face-to-face activities enforced by health authorities.
Title | Hours | ECTS | Learning Outcomes |
---|---|---|---|
Type: Directed | |||
Lectures | 110 | 4.4 | |
Type: Supervised | |||
Seminars | 30 | 1.2 |
Students must pass a final exam to demonstrate that they have reach an acceptable degree of acknowledge on the different topics discussed in the module. The written responses will constitute the prove of the level reached.
From each theme, students must respond to 2-3 questions regarding the topics included in the theme
Finally, students must present and discuss special topics of the module to the rest of the class
Student's assessment may experience some modifications depending on the restrictions to face-to-face activities enforced by health authorities.
Title | Weighting | Hours | ECTS | Learning Outcomes |
---|---|---|---|---|
Exams | 50 | 5 | 0.2 | 2, 4, 5, 6, 8 |
Papers review | 30 | 4 | 0.16 | 1, 3, 10, 8, 9 |
Seminars | 20 | 1 | 0.04 | 3, 11, 7, 9 |
The student will receive a list of references via Campus Virtual