Degree | Type | Year | Semester |
---|---|---|---|
2502442 Medicine | OT | 3 | 0 |
2502442 Medicine | OT | 4 | 0 |
2502442 Medicine | OT | 5 | 0 |
2502442 Medicine | OT | 6 | 0 |
It is necessary for the student to assimilate basic skills in Biochemistry and Molecular Biology and also in Physiology and Pathology.
The subject aims to introduce the student to the clinical applications of Molecular Pathology, both from the point of view of diagnosis, and in the detection of molecular alterations of predictive interest in personalized oncological treatments.
Specialized seminars (15 hours)
Seminar 1
Applied molecular biology (introduction to the primary structure of nucleic acids, higher structures and condensation of DNA, cell cycle and organization of the eukaryotic genome, replication and transcription, genetic code and mechanisms of translation regulation).
Seminar 2
Diagnostic molecular pathology in colorectal and gastric neoplasms
Seminar 3
Diagnostic molecular pathology in lymphoid neoplasms
Seminar 4
Diagnostic molecular pathology in lung neoplasms
Seminar 5
Diagnostic molecular pathology in gynecological and breast neoplasms
Seminar 6
Introduction to basic techniques
Seminar 7
Hybridization techniques: Basics. Conventional cytogenetics techniques. FISH (probe types, CEP / LSI / WCP, hybridization strategies: Dual-Color Break-Apart, Dual-Color Dual-Fusion; amplification probes). CISH. SISH.CGH.
Seminar 8
PCR based techniques (I).
Seminar 9
PCR based techniques (II)
For the 2019-2020 academic year, the professor designated by the Department as responsible for the subject at the Faculty level is:
UDPT
Francisco Javier Andreu
xandreu@tauli.cat
(12 students)
The students, divided into groups of 3 or 4 students, will face real clinical problems that they will have to develop from the initial diagnostic material (paraffin block), through the DNA extraction and quantification method, PCR / hybridization, and sequencing , until the issuance of the molecular pathology report.
The selected cases of the pathology file may include mutational study of lung and colon cancer, study of a family with suspected HNPCC (Lynch syndrome) or diagnosis of limfoproliferatiu process, among others.
In the current exceptional circumstances, at the discretion of the teachers and also depending on the resources available and the public health situation, some of the theoretical classes, practicals and seminars organized by the Teaching Units may be taught either in person or virtually.
Title | Hours | ECTS | Learning Outcomes |
---|---|---|---|
Type: Directed | |||
Specialized Seminars (SESP) | 15 | 0.6 | |
Type: Supervised | |||
Assistencial practicum without guidelines | 15 | 0.6 | |
Type: Autonomous | |||
Personal study, bibliography consultation, problem solving, work accomplishment | 41 | 1.64 | 1, 3, 4, 6, 5, 7, 8, 2 |
The marks for the final qualification of the subject will be:
- The resolution of problems in class (30% of the final grade)
- Completing a written test questionnaire (30% of the final grade). Assessment will take into account the qualification of the presentation and the attitude in class. The non-active participation in the presentation of the corresponding presentation will prevent the qualification of this part of the subject.
- The evaluation of the work (40% of the final grade). The student will have to make a presentation on the case that will have developed during the intensive practice.
Students who fail to carry out both theoretical and practical evaluation tests will be considered as Not evaluated by exhausting the rights to the matriculation of the subject.
Recovery system:
For students who have not passed the subject through the scheduled assessment activities, they can participate in an oral recovery test, according to the programmed exam calendar.
Title | Weighting | Hours | ECTS | Learning Outcomes |
---|---|---|---|---|
Delivery of work / reports | 40% | 1 | 0.04 | 1, 3, 4, 6, 5, 7 |
Evaluation through practical cases and problem solving in class | 30% | 1 | 0.04 | 6, 5, 8, 2, 9 |
Written test questionnaire | 30% | 2 | 0.08 | 6, 5 |
Specific bibliography
Molecular biology and genetic engineering. Luque J, Herráez A. Ed. Elsevier Science, Madrid, 2002.
Lliçons de Molecular Pathology. González Sastre F, Guinovart JJ. Ed. Springer-Verlag Ibérica, Barcelona, 2000.
Molecular Biology of the Gene (2006) Watson et al. Editorial Panamericana.
Reference bibliography
Molecular Biology of the Cell. Alberts B. Ed. Omega, Barcelona 2010.
Internet resources
http://www.sanger.ac.uk/genetics/CGP/cosmic/
www.ncbi.nlm.nih.gov/pubmed
www.ncbi.nlm.nih.gov/omim
http://www.hgvs.org/mutnomen/