This version of the course guide is provisional until the period for editing the new course guides ends.

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Immunology

Code: 101008 ECTS Credits: 6
2024/2025
Degree Type Year
2500502 Microbiology OB 2

Contact

Name:
Angel Raul Castaņo Garcia
Email:
raul.castano@uab.cat

Teaching groups languages

You can view this information at the end of this document.


Prerequisites

Students must have got the learning competences of the courses programmed during the first course of the Degree. It is highly recommended some formation in Biochemistry, Cytology, Anatomy, Genetics and Cell Biology.

 


Objectives and Contextualisation

CONTEXTUALIZATION AND OBJECTVES

Immunology is an obligatory course, specific of the Microbiology degree and included in the Area “Sanitary Microbiology”. Immunology introduces students in the study of physiological and pathological mechanisms of defence and specific response of the organisms against the presence of antigens, as microorganisms and toxins. This course is integrative and students can address the inter-relation between pathogens and hosts from their knowledge acquired in cell biology, microbiology, biochemistry, genetics and animal biology.

Objectives of the course:

The 6 ECTS course of Immunology is split in three blocks with different objectives that the student will have to achieve at the end of the course.

Block I. Basic Immunology

•          to know the concepts of innate and specific immunology and to recognize the important role of each of them during the response against pathogens.

•          to identify the elements that play a role in both responses.

•          to enumerate and explain the structural and functional features of the molecular and cellular components of the innate and adaptive immunity.

•          to explain the features of the lymphoid organs and the recirculation of lymphocytes.

Block I. Organization of the Immune Response

•          to integrate the elements described in the lessons of the Block I with the three phases of the immune response: 1) activation phase; 2) effector phase; and 3) regulation phase and homeostasis.

•          to identify the type of immune responses activated for each infectious agent: bacteria, virus, fung and parasites.

Block III. Immunopathology and Immunotherapy

•          to identify the disfunction of the immune system which is the cause of the immunopathologies: hypersensitivity, immunodeficiencies and autoimmunity.

•          to analyze the association of an ineficient response against infectious agents and certain immunopathologies.

•          to associate the targets of the immune response of different palliative and profilactic treatments.


Learning Outcomes

  1. CM14 (Competence) Integrate knowledge and skills in the field of microbiology applied to health, working individually and in groups, to prepare and present in writing or orally and publicly a scientific work either in English or in one's own language or others.
  2. KM19 (Knowledge) Identify the cellular and molecular relationships established between a microorganism or parasite and its host, including physiological and pathological mechanisms of defence and host response.
  3. SM19 (Skill) Use bibliography or internet tools, both in English and in one's own language or others, for the study of pathogenic microorganisms and their control.
  4. SM21 (Skill) Relate the characteristics of pathogens and their mechanisms of virulence and pathogenicity with the type of infection, the pathology and the immune response that develops and with the mechanisms of action of vaccines and antimicrobial agents.

Content

Each block is divided in teaching units (TU) organized by lessons defining the specific learning descriptors associated to the corresponding competences.

Block I. BASIC IMMUNOLOGY: ELEMENTS OF THE IMMUNE SYSTEM

Lesson 1 & 2. Introduction

Lesson 3. Organization of the organs of the immune system

TU-1. Innate immunity

Lesson 4. Innate immunity

Lesson 5 & 6. Cells of the innate immunity

Lesson 7. The complement system

TU-2. Antigen specific receptors, presenting molecules and antigen recognition

Lesson 8. Structure of immunoglobulins

Lesson 9. Organization of the genes of immunoglobulins

Lesson 10. B lymphocytes 

Lesson 11. Structure and function of the Major Histocompatibility Complex (MHC) molecules

Lesson 12. Antigen processing and recognition

Lesson 13. Genetic organization of the MHC

TU-3. Cells of the adaptative immune system

Lesson 14. T cell receptor (TCR)

Lesson 15. T lymphocytes

Lesson 16. Cytokines and chemokines

Lesson 17. Leukocyte recirculation

Block II. ORGANIZATION OF THE IMMUNE RESPONSE

UD-4. Immune response

Lesson 18. Cellular immune system I

Lesson 19. Cellular immune system II

Lesson 20. Humoral immune system I

Lesson 21. Humoral immune system II

Lesson 22. Regulation of the immune response

UD-5. Immune response against pathogens and mechanisms of action

Lesson 23. Immune response against bacteria, fungs and parasites I

Lesson 24. Immune response against bacteria, fungs and parasites II

Lesson 25. Immune response against virus

Block III. IMMUNOPATHOLOGY AND IMMUNOTHERAPY

UD-6. Immunopathology

Lesson 26. Reactions of hypersensitibity 

Lesson 27. Autoimmunity

Lesson 28. Immunodeficiencies I

Lesson 29. Immunotherapy. Vaccines

Lesson 30. Tumor immunology

 


Activities and Methodology

Title Hours ECTS Learning Outcomes
Type: Directed      
Seminars 15 0.6 CM14, KM19, SM19, SM21, CM14
Theory lessons 30 1.2 CM14, KM19, SM19, SM21, CM14
Type: Autonomous      
Preparation of a review article (bibliographic search, reading, experimental techniques) 17 0.68 CM14, KM19, SM19, CM14
Resolution of cases / ABP (bibliographic search, text reading and evaluation of the cases) 17 0.68 CM14, KM19, SM19, SM21, CM14
Study 66 2.64 CM14, KM19, SM19, SM21, CM14

Educational activities programmed for the course of Immunology of Microbiology degree are:

-       EXPOSITIVE LESSONS

Lessons of the Didactive Units (UD) will be teached in 30 sessions.

-       SEMINARS

For the seminars, the group will be split in two subgroups, G1-IMM and G2-IMM, with an estimated number of 30 students per group. A total of 15 sessions per group will be given with the following programmed activities:

  1. REVIEW ARTICLE (REV, 8 sessions).
  2. CASES (ABP, 4 sessions).
  3. AUTOEVALUATION (AUT, 2 sessions).

Each classroom practice session will last 50 minutes. Information on each topic and application guidelines will be uploaded to the UAB Virtual Campus (Moodle). Students will raise doubts in tutorial sessions with the teacher

1 THEME REVIEWS (REV)

This activity will consist of the oral presentation of a review article corresponding to a thematic set of those already given in class, where the doubts or questions that the class, or where appropriate the teacher, raise in each session can be resolved. The final objective is to know how to search for and select appropriate information and develop it in public, selecting, synthesizing and conceptualizing the most relevant aspects of interest of the topic to the specific audience (Immunology students with intermediate level knowledge). There will be 8 sessions in which a review will be presented and questions will be asked.

2 PROBLEMS BASED LEARNING (ABP)

4 problem-based learning (PBL) sessions have been scheduled, based on original articles of applied research on the immune response against pathogens. To solve the cases, the cooperative learning methodology will be applied. Students will have to work on the corresponding article in its entirety to understand, analyze, develop and defend it in public, as well as ask questions about the results, their interpretations,the consequences and the relationship with the syllabus. The final objective is to know how to clearly present a scientific work in public (introduction, statement of the hypothesis, presentation and interpretation of the results and discussion thereof), defend it with an analytical spirit and develop relevant questions about the different aspects.

Annotation: Within the schedule set by the centre or degree programme, 15 minutes of one class will be reserved for students to evaluate their lecturers and their courses or modules through questionnaires.


Assessment

Continous Assessment Activities

Title Weighting Hours ECTS Learning Outcomes
Cases 10% 0 0 CM14, KM19, SM19, SM21
Partial exam 1 40% 2.5 0.1 CM14, KM19, SM19
Partial exam 2 40% 2.5 0.1 CM14, KM19, SM19, SM21
Review article 10% 0 0 CM14, KM19, SM19

Evaluation of the course will be individual and continuous through the next proves:

-       Individual learning by parcial exams.

-       Cooperative learning through forming activities during the seminar lessons.

The evaluation activities are:

Partial exams: Two partial exams are scheduled, at the end of Blocks I and III. Each test will be worth 40% of the final grade. They will be multiple choice exams with 5 options to choose one. In the correction, 1/5 of the value of each question will be subtracted for incorrect answers. The duration of each test will be a minimum of 2 hours. To weight the grades of the midterm exams, the student will have to obtain a minimum of 4 points in both midterms. The subject can be passed by partial exams as long as the average between the two tests and the PAUL is at least 5 (and 4 has been exceeded in both partial exams). The midterm exams are recoverable subjects..

PAUL reviews (REV): The students will carry out a bibliographic search and select reviews corresponding to different thematic blocks. The sessions will consist of the presentation of the topic by the group and solving the questions of the class and the teacher about it. The evaluation of the oral presentation will represent 10% of the final grade. The content, oral presentation, clarity of the slides and defense of the topic will be valued. The note will be individual..

PAUL cases (ABP): The cases are presented as cooperative work in groups of 7 students. They can be original articles on applied research on the immune response against pathogens or clinical cases. The final objective is to develop comprehensive self-learning capabilities, know how to clearly present a scientific work in public (introduction, statement of the hypothesis, presentation and interpretation of the results and discussion thereof), defend it with a critical spirit and propose relevant questions. on the different aspects (techniques, methodology, results, interpretations, possibilities for future development). The evaluation of the cases will represent 10% of the final grade and their oral presentation, the answer to questions about it and the posing of questions to another group will be evaluated. The grade will be given for the entire group and it will be the students who will have to distribute the grade depending on the effort and individual contribution to the group.

Retake exam: A final exam will be scheduled for students who have not obtained the minimum necessary (less than 5 in the total of the subject or less than 4 in any of the partial exams) or who want to raise their grade. The exam will have a value of 80% of the grade to which the grade percentage of the cases and the article will be added. This final exam will mainly consist of 40-50 multiple choice questions. The duration of the test will be a minimum of 2 hours.

Students who want to raise their grade in the final exam must renounce the grade they have in the midterm exams (corresponding to 80% of the final grade) and will keep the grade they get in the final exam.

To be eligible for the retake process, the student should have been previously evaluated in a set of activities equaling at least two thirds of the final score of the course or module. Thus, the student will be graded as "Not Evaluable" if the weighting of all conducted evaluation activities is less than 67% of the final score.

 

Unique assessment
										
											
										
											The total set of theory (80%) can be examined in a singlea ssessment on the day of the second part of the course.
										
											
										
											The same recovery system will be applied and on the same day as for the continuous assessment.
										
											
										
											The revision of the final qualification follows the same procedure as for the continuous assessment.
The assessment of ABP (10%) and REV (10%) will be done in sessions in group, as in these cases, different transversal competencies will be evaluated which cannot be made individually in the unique assessment.

 


Bibliography

BIBLIOGRAPHY

  • Books in English:

Janeway’s Immunobiology by K Murphy. Ltd/Garland Science, NY & London, 8th ed., (2012).

Kuby Immunology (with web support) by J.A. Owen, J Punt, S. A. Stranford. W.H. Freeman Co., 7th ed, (2013).

Cellular and Molecular Immunology by Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai. Saunders, 8th ed, (2014).

Roitt's Essential Immunology, by Peter Delves, Seamus Martin, Dennis Burton, Ivan Roitt. Wiley-Blackwell Ed., 12th ed., (2011).

Immunology, 7 th Edition by David K. Male, Jonathan Brostoff, Ivan Maurice Roitt, David B. Roth Mosby Elsevier Ed. (2006).

 

Immunology, Infection and Immunity by Pier GB, Lyczak JB & Wetzler LM. ASM International (2004).

Medical Microbiology and Immunology by Warren Levinson. Lange Medical Books / McGraw-Hill, 10 th ed. (2006).

Review of Medical Microbiology and Immunology by Warren Levinson. Lange Basic Sicence / McGraw - Hill, 11th (2010).

 

  • Books in Spanish:

IMMUNOBIOLOGIA: El sistema inmunitario en condiciones de salud y enfermedad de C. Janeway Jr., P. Travers, L. Walport, M. J. Shlomchik. Traducción de la 4ª edición. Editorial Masson, S.A. Barcelona, (2003).  

Inmunología Celular y Molecular de A.Abbas, W. Lichtman, R. Pober. W. B. Saunders Co., Philadelphia, 5ª edición, (2004).  

Introducción a la Inmunología Humana de L. Faimboim, J. Geffner. Ed Medica Panamericana, 5ª edición (2005).

Kuby Immunology (en español) by T.J. Kindt, R.A. Goldsby, B.A. Osborne. W.H. Freeman Co., 6 th ed, (2007).

Inmunología de P. Parham. Ed. Panamericana, 2ª ed. (2006).

Fundamentos de Inmunología de Roitt,I. M. Panamericana, 10ª ed. (2003). 

Inmunología de I. Roitt, J. Brostoff, D. Male.  Hartcourt Brace, 5ª ed. (2003).

 

COMPLEMENTARY BIBLIOGRAPHY. 

  • Journals

Advances in Immunology

http://www.elsevier.com/wps/find/bookdescription.cws_home/716912/description#description

http://www.sciencedirect.com/science/bookseries/00652776

Annual Review of Immunology

http://arjournals.annualreviews.org/loi/immunol

Current Opinion in Immunology

http://www.elsevier.com/wps/find/journaldescription.cws_home/601305/description#description

http://www.sciencedirect.com/science/journal/09527915

Journal of Microbiology, Immunology and Infection

http://www.jmii.org/

Microbiology and Immunology

http://www.wiley.com/bw/journal.asp?ref=0385-5600

        http://www3.interscience.wiley.com/journal/118503650/home

Nature Reviews in Immunology

http://www.nature.com/nri/index.html

Seminars in Immunology

http://www.elsevier.com/wps/find/journaldescription.cws_home/622945/description#description

Trends in Immunology

http://www.cell.com/trends/immunology/

Trends in Microbiology

http://www.cell.com/trends/microbiology/

 

  • WEBS

Immunobiology by C. A. Janeway, P. Travers, M. Walport and M. Shlomchik. Garland Science2001

http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm

Roitt's Essential Immunology, by Peter Delves, Seamus Martin, Dennis Burton, Ivan Roitt. Wiley-Blackwell Ed., 11 th ed., (2006).

http://www.roitt.com/

Kuby Immunology (with web support) by T.J. Kindt, R.A. Goldsby, B.A. Osborne. W.H. Freeman Co., 6 th ed, (2006).

http://www.whfreeman.com/kuby/

http://bcs.whfreeman.com/immunology6e/

Microbiology and Immunology On line. School of Medicine, University of South Carolina

http://pathmicro.med.sc.edu/book/welcome.htm

Faculty of Medicine, Dalhouse University (Halifax, Nova Scotia, Canada)

http://immunology.medicine.dal.ca/bookcase/

The Infectious Diseases WebLink

http://webpages.charter.net/deziel/

Immunobiology

http://www.skidmore.edu/academics/biology/courses/erubenst/BI348/pages/resources.html

 Janeway's animations (també en podeu trobar d'animacions del llibre Janeway's Immunology a la web del yooutube)

http://www.blink.biz/immunoanimations/


Software

- Microsoft PowerPoint.

- Adobe PDF.


Language list

Name Group Language Semester Turn
(SEM) Seminars 721 Spanish first semester morning-mixed
(SEM) Seminars 722 Spanish first semester morning-mixed
(TE) Theory 72 Spanish first semester afternoon