Genetics
Code: 100853 ECTS Credits: 6| Degree | Type | Year |
|---|---|---|
| 2500251 Environmental Biology | FB | 1 |
Contact
- Name:
- Maria del Pilar Garcia Guerreiro
- Email:
- mariapilar.garcia.guerreiro@uab.cat
Teaching groups languages
You can view this information at the end of this document.
Prerequisites
It is assumed that students have acquired the basic knowledge of Biology during high school and a revision of the baccalaureate book is recommended to those who have not studied this subject previously.
The student must have passed the laboratory safety and biosecurity test, and be knowledgeable and accept the laboratories operating regulations at the Biosciences School
Objectives and Contextualisation
This course takes place in the first year of Environmental Biology degree and discusses the fundamental principles of Genetics starting with Mendelian Genetics and concluding with Population Genetics and Evolution. This subject has its continuity the third year with the subject of Phylogeny.
The main objective of this course is that students receive a general introduction to the basic principles of Genetics and understand the inheritance principles, their cytological and molecular basis, and the variation at the molecular and populational level.
The educational objectives are the following:
1) To understand the need for the study of genetics in the context of environmental Biology and the relation of genes to the environment.
2) To know the principles of genetic information transmission, the chromosomal theory of inheritance and be able to perform genetic maps and interpret pedigrees
3) To know the structure, organization, function of the genetic material
4) To know how to use and interpret genome databases and to understand the fundamentals of bioinformatic analysis
5) To know the sources of genetic variability, how measuring and interpret it from a perspective of genetic improvement, conservation and evolution.
Competences
- Act with ethical responsibility and respect for fundamental rights and duties, diversity and democratic values.
- Apply ICT resources pertaining to this field of study.
- Describe, analyse and interpret the vital adaptations and strategies of the principal groups of living beings.
- Identify and interpret the diversity of species in the environment.
- Identify organisms and recognise the different levels of biological organisation.
- Integrate knowledge of different organisational levels of organisms in their functioning.
- Introduce changes in the methods and processes of the field of knowledge to provide innovative responses to the needs and demands of society.
- Solve problems.
- Take sex- or gender-based inequalities into consideration when operating within one's own area of knowledge.
Learning Outcomes
- Act with ethical responsibility and respect for fundamental rights and duties, diversity and democratic values.
- Actuar en l'àmbit de coneixement propi avaluant les desigualtats per raó de sexe/gènere.
- Apply ICT resources pertaining to this field of study.
- Describe the principles of genetic transmission in living beings across the generations.
- Identify the structural and functional characteristics of nucleic acids and their levels of organisation.
- Introduce changes in the methods and processes of the field of knowledge to provide innovative responses to the needs and demands of society.
- Measure and interpret genetic variation within and between populations from the perspective of evolution, conservation, and genetic improvement of animals and plants.
- Recognise the molecular, genetic, tissue- and organism-based levels of organisation.
- Solve problems.
Content
1. Introduction
Why study Genetics? Genetics and human problems. Genetics and Biology. Genes and the environment: genotype and phenotype. Genetic analysis techniques.
2. Mendelian analysis
The Medel's experiments. Principles of segregation and independent transmission. Mendelian genetics in humans and agriculture.
3. Determination of sex and the chromosomal theory of inheritance
Sex determination. Mitosis and meiosis. The genes are on the chromosomes. Sex chromosomes and sex linkage.
4. Extension of the Mendelian analysis
Relations of dominance. Multiple alleles. Lethal genes. Gene interaction and epistasis. Penetrance and expressivity.
5. Genetic linkage: basis of chromosomal mapping in eukaryotes
The discovery of genetic linkage: recombination. Linkage maps: calculation of recombination frequency between two points. Three point maps. Interference. The chromosomal crossover.
6. Mutation
Genetic mutations: somatic and germinals. Induction of mutations. Mutation and cancer. Mutagens in genetic analysis. Chromosomal mutations: structural and numerical.
7. Population genetics.
The Darwin Revolution. Genetic variation and its sources. The selection. Balanced polymorphisms. The adaptive landscape. Artificial selection. Randomness in populations: genetic drift and founder effect. Variation and divergence in populations. Conservation genetics
8. Structure and DNA replication
Semiconservative replication. The mechanism of DNA replication: origin of replication. Replication in eukaryotes.
9. DNA Function: Transcription and Translation
RNA and RNA polymerase. Initiation, elongation and termination. Introns and exons. Messenger RNA and its processing. Genetic code. Concept of codon. The transfer RNA. Degeneracy of genetic code.Protein synthesis: the ribosome. Initiation, elongation and termination.
10. Genomics
Low and high resolution physical maps. Genome sequencing strategies. Organization of DNA sequences. Sequencing of the human genome. Functional genomics. Bioinformatics.
Activities and Methodology
| Title | Hours | ECTS | Learning Outcomes |
|---|---|---|---|
| Type: Directed | |||
| Laboratory practices | 6 | 0.24 | 3, 4, 7 |
| Lectures | 30 | 1.2 | 4, 5, 8 |
| Practices in computer rooms | 8 | 0.32 | 3, 7, 9 |
| Problems/Seminars | 10 | 0.4 | 4, 9 |
| Type: Supervised | |||
| Tutorials | 6 | 0.24 | 5, 7, 9 |
| Type: Autonomous | |||
| Bibliographical searches | 6 | 0.24 | 3 |
| Problem solving | 19 | 0.76 | 9 |
| Reading of prescribed texts | 8 | 0.32 | 3, 9 |
| Study | 50 | 2 | 3, 7 |
Lectures:
Expository sessions with TIC support. In these sessions, a relevant role is granted to the acquisition of knowledge, focusing on the acquisition of the concepts and contents of the subject. They also allow a synthesis of diverse information sources and facilitate the understanding of complex issues.
Classroom practices:
Sessions in smaller groups that allow to deepen in the master class and to work correctly each topic. In these sessions, students' skills in applying theoretical knowledge to solve practical problems are promoted, along with their participation in solving problems on the blackboard and discussing practical cases.
Laboratory practices:
Based on laboratory practices of compulsory attendance considered fundamental for Genetics as an experimental discipline. The practices consist of 4 sessions conducted in small groups to promote cooperative learning. The students will work, in the first two sessions, with living material crosses to elaborate a 3 loci genetic map. In the third session, students will work with population data on a certain character they have previously collected and then used to perform estimates of different population parameters. In the last session, students are shown the applications of bioinformatics to genetic research. This session allow them to familiarize themselves with different computer tools aimed at predicting the future of populations under given conditions.
Individual student tutorials:
One-to-one tutorials where the student has the possibility to raise specific doubts related to the topics. It is a valuable teaching complement allowing to individualize and to personalize the teaching.
Annotation: Within the schedule set by the centre or degree programme, 15 minutes of one class will be reserved for students to evaluate their lecturers and their courses or modules through questionnaires.
Assessment
Continous Assessment Activities
| Title | Weighting | Hours | ECTS | Learning Outcomes |
|---|---|---|---|---|
| 2 midterm tests | 30% and 40% of the final grade respectively | 5.5 | 0.22 | 2, 3, 4, 5, 6, 7, 8, 9 |
| Evaluation of problems/room activities | 10% of the final grade | 1 | 0.04 | 1, 2, 3, 7, 9 |
| Examination of laboratory practices | 20% | 0.5 | 0.02 | 1, 3, 6, 7, 9 |
The assessment of this subject is continuous and will include two midterm exams to assess the theory and problem contents, a questionnaire of each laboratory practice and the participation in proposed work in class, problem solving and class participation
The system of evaluation in which the specific weight of each part is considered will be as follows:
- Midterm exams corresponding to the lectures and seminars: this part will have an overall specific weight of 70%. Two qualifying written tests will be carried out with specific weights of 30% and 40% respectively.
- Laboratory practices: specific weight of 20%
- Participation in class work, problem solving and class participation: overall specific weight of 10 %
The student will pass the course if the global average grade is equal to or higher than 5 and the following minimum performance requirements are established:
- To have attended all the laboratory practices and obtained in each session a mark equal to or higher than 5. The final practice mark is the arithmetic mean of the marks obtained in each of the individual sessions
-To have obtained in each of the midterm tests a grade ≥5.
The student will be able to overcome any failed midterm exam or to improve the grade through a second-chance exam at the end of the course. If the student do this exam to improve the grade, only the grade of the last exam will be valid. To be eligible for the retake process, the student should have been previously evaluated in a set of activities equaling at least two thirds of the final score of the course or module. Thus, the student will be graded as "No Avaluable" if the two thirds of the final score of the course or module. Thus, the student will be graded as "No Avaluable" if the weighthin of all conducted evaluation activities is less than 67% of the final score
Single Assessment
The single assessment consists of a single summary test in which the contents of the entire theory and exercices program of the subject will be assessed. The test will consist of questions of the same type as the continuous assessment exam. The grade obtained in this synthesis test will account for 70% of the final grade of the subject.
Attendance to laboratory practices is compulsory
In the case of deliveries and laboratory practices, the same procedure will be followed as for the continuous evaluation. The grade obtained will account for 10% and 20% of the final grade of the subject respectively.
In order to pass the subject, a final minimum grade of 5/10 in the synthesis test as well as in each of the laboratory practices is required.
The single evaluation test will be carried out coinciding with the same date set in the calendar for the last continuous evaluation test and the same recovery system will be applied as for the continuous assessment
Bibliography
1) Benito, C., F.J. Espino. Genética. (2013). Conceptos esenciales. Ed. Médica Panamericana. Online UAB library access (https://bibcercador.uab.cat/permalink/34CSUC_UAB/1eqfv2p/alma991007006939706709)
2) Griffiths, A.J.F., S.R. Wessler, R.C. Lewontin, S.B. Carroll. (2008). Genética. 9ª edició. McGraw-Hill/Interamericana, Madrid.
3) Pierce, B.A. 2016. Genética un enfoque conceptual (5ª edició). Ed. Médica Panamericana. Online UAB library access (https://bibcercador.uab.cat/permalink/34CSUC_UAB/1eqfv2p/alma991007006939706709)
4) Pierce, B.A. 2011. Fundamentos de Genética. Conceptos y relaciones (1ª edición). Ed. Médica Panamericana.
5) Pierce, B.A. 2020. Genetics: A conceptual approach (7th edition). Ed. W.H. Freeman & Company. Online UAB library access (https://bibcercador.uab.cat/permalink/34CSUC_UAB/avjcib/alma991010703420506709)
6) Frankham R., J.D. Ballou, D.A. Briscoe. 2010. Introduction to conservation genetics. Cambridge University press.
Exercices:
1) Benito, C. 1997. 360 problemas de Genética. Resueltos paso a paso. Editorial Síntesis, Madrid.
2) Elrod, S. & Stansfield, W.D. 2002. Schaum´s Outline of Genetics. Fourth edition. Mc Graw-Hill, USA.
3) Jiménez, A. Problemas de Genética para un curso general. Colección manuales uex. Universidad de Extremadura, 2008.
4) Ménsua, J.L. 2003. Genetica. Problemas y ejercicios resueltos. Pearson Prentice Hall, Madrid.
Web links: https://cv.uab.cat/
Software
Language list
| Name | Group | Language | Semester | Turn |
|---|---|---|---|---|
| (PAUL) Classroom practices | 211 | Catalan/Spanish | second semester | morning-mixed |
| (PAUL) Classroom practices | 212 | Catalan/Spanish | second semester | morning-mixed |
| (PLAB) Practical laboratories | 211 | Catalan | second semester | morning-mixed |
| (PLAB) Practical laboratories | 212 | Catalan | second semester | morning-mixed |
| (PLAB) Practical laboratories | 213 | Catalan | second semester | morning-mixed |
| (TE) Theory | 21 | Spanish | second semester | afternoon |