Advanced Genomics and Proteomics
Code: 43473 ECTS Credits: 9| Degree | Type | Year | Semester |
|---|---|---|---|
| 4313794 Biochemistry, Molecular Biology and Biomedicine | OT | 0 | 1 |
Contact
- Name:
- Julia Lorenzo Rivera
- Email:
- julia.lorenzo@uab.cat
Teaching groups languages
You can check it through this link. To consult the language you will need to enter the CODE of the subject. Please note that this information is provisional until 30 November 2023.
Teachers
- Francesc Xavier Avilés Puigvert
- Antoni Barbadilla Prados
- Enric Querol Murillo
- Jaime Luis Martinez Urtaza
- Julia Lorenzo Rivera
- Sonia Casillas Viladerrams
Prerequisites
The Catalan, English or Spanish languages will be mostly used depending of the lecturer that will give a particular topic and the conjoint of attendees.
Addressed to post-graduate students in Biochemistry, Biotechnology, Biology, Biomedicine, Genetics, Microbiology, Chemistry, Informatics/Bioinformatics, Pharmacy, Medicine and Veterinary.
Objectives and Contextualisation
The overall aim of the subject is to provide students with an overview of Genomics and Proteomics, including the fundamentals, common techniques, and applications. The specific objectives of GENOMICS include understanding the following aspects. the diversity and complexity of eukaryotic genomes, the historical and evolutionary perspective of genomic content, the meaning and consequences of intraspecific variability, techniques commonly employed in studies of genomics and transcriptomics, and applications derived from the knowledge provided by this science.
The objective of the PROTEOMICS classes is to introduce students to new methods of proteomics and interactomics and their application in biomedical research. It aims to understand how proteins interact and regulate each other, how they change in response to diseases or treatments, and how these alterations can be used to diagnose diseases, identify biomarkers, or develop new therapeutic approaches.
Competences
- Analyse and correctly interpret the molecular mechanisms operating in living beings and identify their applications.
- Communicate and justify conclusions clearly and unambiguously to both specialist and non-specialist audiences.
- Continue the learning process, to a large extent autonomously.
- Develop critical reasoning within the subject area and in relation to the scientific or business context.
- Identify and use bioinformatic tools to solve problems in biochemistry, molecular biology and biomedicine.
- Integrate contents in biochemistry, molecular biology, biotechnology and biomedicine from a molecular perspective.
- Solve problems in new or little-known situations within broader (or multidisciplinary) contexts related to the field of study.
- Use and manage bibliography and IT resources related to biochemistry, molecular biology or biomedicine.
- Use scientific terminology to account for research results and present these orally and in writing.
Learning Outcomes
- Communicate and justify conclusions clearly and unambiguously to both specialist and non-specialist audiences.
- Continue the learning process, to a large extent autonomously.
- Develop critical reasoning within the subject area and in relation to the scientific or business context.
- Identify and describe the different components in prokaryotic and eukaryotic genomes and proteomes.
- Identify molecular mechanisms responsible for diseases.
- Solve problems in new or little-known situations within broader (or multidisciplinary) contexts related to the field of study.
- Use and manage bibliography and IT resources related to biochemistry, molecular biology or biomedicine.
- Use scientific terminology to account for research results and present these orally and in writing.
- Use the different methodologies, techniques and tools commonly used in genome sequencing, assembly and annotation.
- Use the different methodologies, techniques and tools commonly used in proteomics and interactomics and metabolomics.
Content
GENOMICS: Introduction to Genomics. The human genome project. Genomic technologies. Transposable elements. Comparative genomics nucleotide-level changes. Comparative genomics: chromosomal changes. Population genomics: Theory. Population genomics in model species. Nucleotide variation in humans. Structural variation. Association Studies/System genetics. Functional Genomics and Transcriptomics. Epigenomics.
PROTEOMICS: Instrumentation and methods of proteomics. Session of proteomics practices. Introduction to biomedical proteomics and its applications: biomarkers in biomedicine; identification of pharmacological targets; Moonlighting proteins in human diseases and in vaccine design. Interactomics and the role of protein interactions in the disease. Applications from proteomics to custom medicine.
Methodology
Annotation: Within the schedule set by the centre or degree programme, 15 minutes of one class will be reserved for students to evaluate their lecturers and their courses or modules through questionnaires.
Activities
| Title | Hours | ECTS | Learning Outcomes |
|---|---|---|---|
| Type: Directed | |||
| Lectures | 45 | 1.8 | 5, 6, 8 |
| Type: Supervised | |||
| Oral presentations | 40 | 1.6 | 1, 7, 8 |
| Type: Autonomous | |||
| Student work and learning | 137 | 5.48 | 3, 5, 6, 2, 7, 8 |
Assessment
Continuos evaluation subject (the unique evaluation does not apply):
Final grades are a weighted average of items:
Important: If plagiarism is detected in any of the works submitted, the student will fail the whole module.
I
Assessment Activities
| Title | Weighting | Hours | ECTS | Learning Outcomes |
|---|---|---|---|---|
| Exams | 40% | 2 | 0.08 | 4, 3, 5, 6, 1, 2, 9, 10, 8 |
| Lecture attendance | 20% | 0 | 0 | 6, 1 |
| Oral presentation | 40% | 1 | 0.04 | 6, 1, 7 |
Bibliography
Expasy: http://www.expasy.org
Human Proteome Map: http://www.humanproteomemap.org/
ProteomicsDB: : http://www.proteomicsdb.org/
Software
None