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2020/2021

Medical Immunology

Code: 102928 ECTS Credits: 4
Degree Type Year Semester
2502442 Medicine OB 3 0
The proposed teaching and assessment methodology that appear in the guide may be subject to changes as a result of the restrictions to face-to-face class attendance imposed by the health authorities.

Contact

Name:
Ricardo Pujol Borrell
Email:
Ricardo.Pujol@uab.cat

Use of Languages

Principal working language:
catalan (cat)
Some groups entirely in English:
No
Some groups entirely in Catalan:
No
Some groups entirely in Spanish:
No

Teachers

Marta Vives Pi
Oscar de la Calle Martin
Juan Francisco Delgado de la Poza
Eva Maria Martinez Caceres
Candido Juarez Rubio
Manuel Hernández González
Aina Teniente Serra
Laura Martinez Martinez
Maria Esther Moga Naranjo
Roger Colobrán Oriol
Mónica Martínez Gallo

External teachers

Bibiana Quirant Sánchez
Clara Franco Jarava
Janire Perurena Priento
Joan Climent Marti
Laura Vińas Gimenez
Maite Sanz Martínez
Romina Dieli Crimi

Prerequisites

It is advisable that the student has attained basic skills in cell biology, biochemistry and molecular biology before enrolling in the immunology course.

It is absolutely necessary to have acquired sufficient knowledge in: general and specific anatomy and physiology of different organs and systems.

The student will preserve the confidentiality and professional secrecy of the data to which he / she may have access through to the learning process in the health care provider facilities. In addition, he/she behavior will follow the professional ethical code.

Objectives and Contextualisation

1) To know the essentials features of the molecular, cellular, anatomical elements of the immune system (SI) and their function in the healthy individual.

2) To understand the role of the immune system in the following pathological processes: 

a. Common infections

b. Allergies and hypersensitivity  in general

c. Immune-mediated diseases, autoimmune, autoinflammatoty and other

d. Immunodeficiencies

e. Cancer

F. Transplantation

 

3) To  understand the basic action mechanisms of immune-based therapies: 

a) Vaccines,

b) Immunosuppressants, 

c) Immunemodulators

 

4) To learn and understand the basis of the laboratory and clinical tests  that have diagnostic value for the immune mediated diseases 

Competences

  • Demonstrate basic research skills.
  • Demonstrate knowledge of the principles and physical, biochemical and biological processes that help to understand the functioning of the organism and its disorders.
  • Demonstrate understanding of the basic sciences and the principles underpinning them.
  • Demonstrate understanding of the functions and interrelationships of body systems at different levels of organisation, homeostatic and regulatory mechanisms, and how these can vary through interaction with the environment.
  • Demonstrate understanding of the manifestations of the illness in the structure and function of the human body.
  • Demonstrate understanding of the mechanisms of alterations to the structure and function of the systems of the organism in illness.
  • Demonstrate understanding of the organisation and functions of the genome, the mechanisms of transmission and expression of genetic information and the molecular and cellular bases of genetic analysis.
  • Demonstrate understanding of the structure and function of the body systems of the normal human organism at different stages in life and in both sexes.
  • Demonstrate understanding of the structure and function of the human organism in illness, at different stages in life and in both sexes.
  • Establish the diagnosis, prognosis and treatment, basing decisions on the best possible evidence and a multidisciplinary approach focusing on the patient's needs and involving all members of the healthcare team, as well as the family and social environment.
  • Formulate hypotheses and compile and critically assess information for problem-solving, using the scientific method.
  • Indicate the basic diagnosis techniques and procedures and analyse and interpret the results so as to better pinpoint the nature of the problems.
  • Maintain and sharpen one's professional competence, in particular by independently learning new material and techniques and by focusing on quality.
  • Organise and plan time and workload in professional activity.
  • Put forward suitable preventive measures for each clinical situation.

Learning Outcomes

  1. Demonstrate basic research skills.
  2. Describe the main forms of preventive immunotherapy, especially vaccines and the mechanism by which they provide protection.
  3. Describe the particular genetic mechanisms that generate unique genes in each lymphocyte during development.
  4. Describe the position and objectives of immunology among the basic health sciences.
  5. Describe the therapy principles applicable to immunomediated diseases.
  6. Differentiate the functions of the immune system and how it interacts with other organ systems and reacts to germs by developing immune defence responses.
  7. Enumerate the main injuries and functional changes that the immune system can cause.
  8. Explain the biochemical and biological bases of the functioning of the immune system.
  9. Formulate hypotheses and compile and critically assess information for problem-solving, using the scientific method.
  10. Identify the indications of immunological tests.
  11. Identify the main mechanisms by which the immune system can cause or contribute to illness.
  12. Identify the paradigmatic diseases of the different types of immunomediated diseases.
  13. Identify the role of should structures and system with organs and and system.
  14. Interpret in the physiological and pathological context the main techniques for determining the state of the immune system and diagnosing immunomediated diseases.
  15. Maintain and sharpen one's professional competence, in particular by independently learning new material and techniques and by focusing on quality.
  16. Organise and plan time and workload in professional activity.
  17. Understand the role of genetic polymorphisms in the immune response.

Content

Contents of the subject by teaching units

 

Block 1 Basic Immunology

 

UD1 Introduction to immunology

UD2 Natural Immunity

UD3 Clonal receptors and their ligands

UD 4 Cells of the immune system

UD5 The immune response, regulation and effectors

 

Block 2 Immunopathology

 

UD6 The immune response in the whole organism and disease

UD7 immune responses in special clinical situations

UD8 Diagnostic tests in clinical immunology

UD9 immunology based therapies

Methodology

This guide describes the contents, methodology and general rules of the course, in accordance with the current curriculum.

The Medical Immunology course runs during a semester and contains many new concepts and theferore attending lectures and daily study is strongly encouraged. Periodically on-line questionnaire will be used to assess the progress in the understanding by the students of the concepts presented and discussed in the lectures and seminars.  Attending at least six keynote lectures is compulsory.

Immunological concepts will be applied by the student to paradigmatic clinical cases presented in seminars. 

Some aspects of the organization of the teaching activities e.g. dates of the practicals and exams, will depend on the particular circumstances and facilities of the different teaching facilities that the university has in each of the UAB affiliated hospitals where the course is imparted.  

For the current academic year, the responsible faculty designated by the department are:

Overall coordination Prof: Ricardo Pujol Borrell

Hospital coordinators

 Vall d'Hebron: Ricardo Pujol Borrell

 Germans Trias i Pujol: Eva Martínez Cáceres

 Sant Pau: Óscar de la Calla and Cándido Juárez

 Parc Taulí: Maria José Amengual

In the current exceptional circumstances, at the discretion of the teachers and also depending on the resources available and the public health situation, some of the theoretical classes, practicals and seminars organized by the Teaching Units may be taught either in person or virtually.

Activities

Title Hours ECTS Learning Outcomes
Type: Directed      
CLASSROOM PRACTICES (PAUL) 2 0.08 7, 9, 11, 12, 14
CLINICAL CASE SEMINARS (SCC) 3 0.12 5, 9, 11, 10, 12, 14
LABORATORY PRACTICALS (PLAB) 3 0.12 10, 14
Specialized seminars (SEM) 2 0.08 17, 3, 5, 2, 6, 7, 8, 13, 11, 10, 12, 14, 15
THEORY (TE) 26 1.04 17, 3, 5, 4, 2, 6, 7, 8, 9, 11, 12, 15
Type: Autonomous      
SELF STUDY.READING ARTICLES/REPORTS OF INTEREST 58.5 2.34 17, 3, 5, 4, 2, 6, 7, 8, 9, 11, 10, 12, 15

Assessment

EVALUATION,

 Continuous assessment

Written Test 1, MCQ and SAQ (60% and 40%) covering basic immunology i.e., material covered in lectures IMM1 to IMM15. 

Written Test 2. MCQ and SAQ (60% and 40%) covering clinical immunology, i.e. IMM16-26   seminars and practicals. The minimal score in each is test is 6

The relative weight of each assessment in the final mark is:  Test 1 30%, Test 2, 45%, on line, practicals and seminar questionnaires, 25%.

Final assessment.

Those students who fail to pass the course through the continuous assessment, will be given the opportunity to take a final global test. This will consist in SAQ and assays. 

 To pass the Medical immunological Course the minimal score is 5. 

Assessment Activities

Title Weighting Hours ECTS Learning Outcomes
ATTENDING LECTURES AND PARTICIPATING IN SEMINARS AS ASSESSED BY ON LINE QUESTIONAIRES 10% 2.5 0.1 17, 3, 5, 4, 2, 6, 7, 8, 9, 13, 11, 12, 15, 16
PRACTICALS AND CASE DISCUSSION AS ASSESSED BT WRITTEN AND ON LINE QUESTIONNAIRES 15% 0.5 0.02 1, 5, 2, 9, 10
WRITTEN EVALUATION :OBJECTIVE TESTS 75% 2.5 0.1 17, 1, 3, 5, 4, 2, 6, 7, 8, 9, 13, 11, 10, 12, 14, 15, 16

Bibliography

Main Textbooks

Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai. Cellular and Molecular Immunology: 9à edició. Elsevier Saunders, 2017. Amb access on line per estudiants; ISBN-13: 978-0323479783

Janeway's Immunobiology. 9th ed. Kenneth Murphy and Casey Weaver (Author)Garland Science, 2017, ISBN-13: 978-0815345053

Other recommended textbooks

Roitt's Essential Immunology, Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt Wiley-Bolcall, 2016. ISBN-13: 978-1118415771

Kuby - Immunology. 7a edició Ed. WH Freeman 2013; en cas de dificultat amb l’anglès es pot usar el “Inmunología” de Kuby, 6a edició en espanyol.

Peter Parham; The Immune System, Garldand Science, 4rd edition, 2014.

Addtional reading

Clinical Immunology, Principles and Practice. Robert R Rich. 4ª edició Mosby, 2019. ISBN-13: 978-0723436911

Internet resources

http://www.roitt.com, Figures, and questionnaires for self assessment

Videos on line

Els increibles videos de microscopia multifotónica de Ronal N Germain

https://www.niaid.nih.gov/research/ronald-n-germain-md-phd