Degree | Type | Year | Semester |
---|---|---|---|
2502445 Veterinary Medicine | OB | 2 | 2 |
Although there are no official prerequisites, it is convenient for the student to review the basic contents of Biology and Biochemistry.
It is a subject of the second year of the Veterinary degree, of a basic nature and in which the student must acquire the theoretical and practical knowledge that will allow him to understand the organization and structure of the genome in prokaryotes and eukaryotes, the mechanisms of gene expression and its regulation at the transcriptional and post-transcriptional levels, as well as knowing the different sources of genetic variation, from point nucleotide mutations to chromosomal rearrangements, and its impact on several phenotypes of veterinary interest. The student will also become familiar with various techniques of genome analysis and genetic variability. The specific training objectives are:
- Familiarize yourself with the basic concepts of Genetics.
- Know the mechanisms that regulate gene expression
- Understand how the transmission of phenotypic characters to offspring occurs.
- Understand the processes through which genetic and environmental factors affect phenotypic variation and the various pathologies of domestic species
- Know the techniques and methods of Molecular Genetics and Structural and Functional Genomics.
The global content of this subject consists of five theoretical blocks: Block 1. Organization and structure of the hereditary material. Block 2. Gene expression. Block 3. Inheritance and genetic variation. Block 4. Analysis of the genome and its applications. Block 5. Immunogenetics and herdopathology. Likewise, the student will become familiar with the resolution of Genetics problems through an approach based on self-learning. This part of the subject will consist of three thematic blocks Block A. Molecular Genetics Problems Block B. Problems of Mendelian Genetics. Block C. Linkage problems
The teaching methodology that will be carried out during the whole learning process is fundamentally based on the student's work, and the teacher will be in charge of guiding him through this process. In accordance with the teaching objectives of the subject, the training activities that will be carried out are:
- Lectures: With these classes, the student acquires the basic scientific-technical knowledge of the subject that must be complemented with the study of the concepts explained.
- Self-learning-Problem solving: Students will be provided with a wide collection of solved problems where the way or ways of approaching and solving them is explained in a very detailed and didactic way. This tool will allow students to become familiar, in an autonomous but guided way, with this more practical aspect of the subject.
- Self-learning-Group work: This activity aims to promote group work, as well as enhance the ability to use computer resources to resolve issues of a biological nature. The student will be given a questionnaire with a series of questions related to the bioinformatic analysis of genetic data (data search, in silico analysis of sequences, navigation through genetic databases, etc.). Likewise, the student will be provided with information that will help him to become familiar with the bioinformatics tools he needs to solve the questionnaire. For example, if you are asked to build a restriction map of a DNA sequence, you will be instructed where to find the online bioinformatics tool to do it and you will also be explained some general notions about its management. The work will be done in groups of 4 students
Title | Hours | ECTS | Learning Outcomes |
---|---|---|---|
Type: Directed | |||
Lectures | 25 | 1 | 1, 2, 5, 4, 7, 6 |
Type: Autonomous | |||
Problem solving | 17 | 0.68 | 1, 5, 7, 6 |
Study | 24 | 0.96 | 1, 2, 5, 4, 7, 6 |
Work on Bioinformatic Resources | 5 | 0.2 | 2, 3 |
The evaluation will be individual and will be carried out continuously in the context of the different training activities that have been programmed. There will be two exams 1 and 2. Both exams will be of the test type (V / F). The first exam will be of Theory and the second of Problems. Students who have failed the exam 1 can recover it on the same day that the exam 2 is held. Students who have passed the exam 1 and want to improve the grade obtained can repeat exam 1, but in this case the student's presentation in the the recovery exam will entail the rejection of the previously obtained qualification. Exam 2 will not be recoverable. A minimun mark of 4 in the two exams is required to make the average qualification.
Likewise, a work will be carried out, in groups of 4 students, consisting of answering a series of questions related to the analysis of DNA sequences and the structural characterization of the genome. The realization of this work will involve the use of a wide variety of bioinformatic tools as well as consult several databases related to Structural Genomics. In the case that a student suspends the subject, the note of the work will be kept for the next course, although you can redo it if you wish to increase the grade (this will entail the rejection of the previously obtained grade) The marks obtained in the exams will constitute 80% of the global mark (Exam 1: 50% overall mark, Exam 2: 30% overall mark). The qualification of the work will constitute 20% of the global mark. The maximum overall score will be 10 points. When the overall score is less than 10 points, it can be rewarded (up to a maximum of 1.5 points) depending on the student's attitude to the subject, class participation and the level of training achieved. The minimum grade to pass the course will be 5 points out of a maximum of 10 points. The students will have the opportunity to review the grades of the exams and the work on theday / time / place indicated by the responsible teachers in the Virtual Campus. Not evaluable: It will be considered that a student is not evaluable if he has participated in evaluation activities that represent ≤ 15% of the final grade.
Title | Weighting | Hours | ECTS | Learning Outcomes |
---|---|---|---|---|
Exam 1: Theory (theoretical blocks 1 to 5) | 50% | 2 | 0.08 | 1, 5, 4, 7, 6 |
Exam 2: Problems (blocks A, B and C) | 30% | 2 | 0.08 | 1, 7 |
Work | 20% | 0 | 0 | 2, 3 |
Text Books
General Genetics:
BROWN T. A. (2002) Genomes. John Wiley and Sons. Tb en format online, accés lliure. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=genomes.TOC&depth=2
GRIFFITHS A. J. F. & OTHERS (1999) Modern Genetic Analysis. Freeman and Co. Tb en format online, accés lliure. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mga.TOC
GRIFFITHS A. J. F. & OTHERS (2007) Genética. McGraw Hill-Interamericana.
LEWIN B. (2004) Genes VIII. Pearson Prentice Hall.
LEWIN B. (2006). Essential Genes. Pearson Prentice Hall.
NICHOLAS F. W. (1998). Introducción a la Genética Veterinaria. Acribia.
NICHOLAS F. W. (2003). Introduction to Veterinary Genetics. Blackwell Publishing.
PIERCE B. A. (2005). Genética, un enfoque conceptual. Panamericana.
Species-specific Genetics:
PIPER L. & RUVINSKY A. (1997). The Genetics of Sheep. CABI Publishing.
ROTHSCHILD M. F. & RUVINSKY A. (1998). The Genetics of the Pig. CABI Publishing.
FRIES R. & RUVINSKY A. (1999). The Geneticsof Cattle. CABI Publishing.
BOWLING A. T. & RUVINSKY A. (2000). The Genetics of the Horse. CABI Publishing.
RUVINSKY A. & SAMPSON A. J. (2001). The Genetics of the Dog. CABI Publishing.
Webs
Online Mendelian Inheritance in Animals - http://omia.angis.org.au/
Inherited Diseases Database in Dogs - http://www.vet.cam.ac.uk/idid/
Canine Inherited Disorders Database - http://www.upei.ca/~cidd/intro.htm
National Center of Biotechnology - http://www.ncbi.nlm.nih.gov
Ensembl - http://www.ensembl.org/index.html
Bovine Genome Database -http://genomes.arc.georgetown.edu/drupal/bovine/