Advanced Biochemical Engineering
Code: 102410 ECTS Credits: 9| Degree | Type | Year | Semester |
|---|---|---|---|
| 2500897 Chemical Engineering | OT | 4 | 0 |
Contact
- Name:
- Jordi Joan Cairó Badillo
- Email:
- JordiJoan.Cairo@uab.cat
Use of Languages
- Principal working language:
- catalan (cat)
- Some groups entirely in English:
- No
- Some groups entirely in Catalan:
- Yes
- Some groups entirely in Spanish:
- No
Prerequisites
The syllabus does not determine any specific prerequisite for this subject. However, due to its integrating nature of the different knowledge acquired throughout previous courses, the recommendation is to have passed the maximum number of subjects possible before taking it. In any case, they are essential to be able to properly track the subjects of the biochemical engineering itinerary.
Objectives and Contextualisation
Introduce to the student the concepts and practice of the bioprocesses and embedding of a set of unit operations (stages of the process) for the production of a product, service or desired at a cost and acceptable quality.
Acquire understanding and practice in the analysis and design of biotechnological processes in terms of engineering, economics, compliance with regulations, quality, intellectual property, etc.
Introduce to the student the most important stages and tools used in the analysis and be able to use these tools in the evaluation and comparison of different solutions (proposals) of design of a specific process.
Overall, it is a subject that intends to integrate / synthesize knowledge of the different scientific disciplines and engineering acquired in other subjects of the degree for the design of bioprocesses.
Competences
- Analyse the economic feasibility of an industrial chemical engineering project.
- Analyse, evaluate, design and operate the systems or processes, equipment and installations used in chemical engineering in accordance with certain requirements, standards and specifications following the principles of sustainable development.
- Apply relevant knowledge of the basic sciences, such as mathematics, chemistry, physics and biology, and the principles of economics, biochemistry, statistics and material science, to comprehend, describe and resolve typical chemical engineering problems.
- Apply the techniques for analysing and synthesising systems to process and product the engineering.
- Communication
- Demonstrate knowledge of the different reaction, separation and processing operations for materials, and transport and circulation of fluids involved in the industrial processes of chemical engineering.
- Develop personal work habits.
- Develop thinking habits.
- Evaluate, in a structured and systematic manner, the health and safety risks in an existing process or one in design phase, and apply the suitable measures to each situation.
- Objectively compare and select different technical options for chemical processes.
- Show an understanding of the role of chemical engineering in the prevention and resolution of environmental and energy problems, in accordance with the principles of sustainable development.
- Understand and apply the basic principles on which chemical engineering is founded, and more precisely: balances of matter, energy and thermodynamic momentum, phase equilibrium and kinetic chemical equilibrium of the physical processes of matter, energy and momentum transfer, and kinetics of chemical reactions
Learning Outcomes
- "Relate and apply known concepts and methods from different subjects (from biology and biochemistry to the principles of chemical engineering) to the analysis and design of bioprocesses; know how, when and where to apply this acquired knowledge."
- Analyse the economic feasibility of an industrial biotechnology project.
- Apply analysis techniques to bioprocess and bioproduct engineering.
- Apply the main concepts of organising and managing a process.
- Correctly describe the diversity of separation processes on different scales.
- Critically evaluate the work done.
- Design and execute properly a protocol for the purification of a biotechnological product.
- Develop critical thinking and reasoning
- Efficiently use ICT for the communication and transmission of ideas and results.
- Identify and apply immobilisation systems and their operation modes.
- Identify and apply the optimisation strategies of biotechnological processes and products.
- Make structured evaluations of irrigation for the health and safety of a biotechnological process.
- Properly apply biosafety requirements to the design of bioprocess operations.
- Properly design and analyse a bioprocess for a certain product, in accordance with the requirements and application being made.
- Propose the suitable design for a bioreactor and its application.
- Use waste and energy consumption minimisation criteria in the design of separation operations.
Content
Biochemical, Biotechnology, and Chemical Engineering.
Process Diagrams
Block diagrams, flow diagrams, P & I, Diagrams of implementation
Historical perspective of biotechnological processes
Actors of the biotechnology process:
The products or services, the biocatalyst, the substrates, the bioreactor.
Parts of biotechnological processes
Upstream, process, downstream
Economic analysis as a basic criterion in the development and scaling of bioprocesses
Interrelation ofthe actors of the bioprocess
Environmental and social analysis
Project engineering, modeling and simulation of bioprocesses (Superpro dessigner, Microsoft project).
2.-Biochemical Engineering applied to human and animal health
Diagnosis and Monitoring:
Production of monoclonal antibodies and antigens.
Biosensors and analytical devices.
Therapy:
Therapeutic proteins and enzymes.
Genetic, cellular and tissue therapies.
Prophylaxis:
Conventional, recombinant and DNA vaccines.
3.- Biochemical engineering applied to industrial and energy processes
Products derived from energy and biosynthetic metabolism:
Alcohols, organic acids, fats, amino acids and vitamins.
Structural and functional products:
Polysaccharides, Polyesters: structure and applications, production.
Proteins and enzymes. Enzymatic processes.
Secondary Metabolites:
Antibiotics and pigments.
Insecticides
4.- Biochemical Engineering applied to food biotechnology and agronomy
Biomass for human and animal nutrition.
Fermentation products: Bread, pasta, wine, beer, cava, dairy products, fermented vegetables and meat.
Use of enzymes.
Flavors, smells and fragrances.
Transgenic and functional foods (nutraceuticals).
5.- Application of Biochemical Engineering in environmental biotechnology
Aerobic and anaerobic biological processes related to physicochemical treatments.
Processes with photosynthetic organisms.
Biorefineries
Biological life support: Life in extreme conditions and colonization of space.
Methodology
Theoretical classes may be taught in person or, if required, virtually, as a practice during the 2019-2020 academic year. In this case, the teacher will determine the modality that can be done (class with virtual platform like teams, preparation of video or powerpoint classes that are posted on the virtual campus). In addition to the theoretical classes, it will be seminars on specific aspects of biotechnological processes. The subject is given in the Moodle Classroom and all the materials used in the classes and seminars will be deposited, plus author articles that allow students who are not interested in deepening their knowledge in a specific topic.
Some of the classes can be done by professionals working in the biotechnology industry, including visits to specific biotechnology research groups.
Students, working in groups of 3 to 5, will have to do a work on a biotechnological process, of their choice, which will be presented in writing and will be discussed in the seminar sessions.
Activities
| Title | Hours | ECTS | Learning Outcomes |
|---|---|---|---|
| Type: Directed | |||
| Theoretical classes | 42 | 1.68 | 1, 2, 13, 5, 8, 14, 10, 16 |
| Type: Supervised | |||
| Seminars | 15 | 0.6 | 1, 2, 13, 6, 5, 8, 14, 7, 9, 10, 16 |
| work in group | 80 | 3.2 | 1, 2, 13, 6, 5, 8, 14, 7, 9, 10, 16 |
| Type: Autonomous | |||
| self study | 80 | 3.2 | 1, 2, 13, 5, 14, 7, 10, 16 |
Assessment
Compulsory group work will represent 25% of the final mark (2,5 points out of 10).
To make the average with the rest of the notes, you must obtain a minimum mark in each part of 40% of the mark (1 points for each written theoretical exams, 1for the group work).
For students who do not pass the written theoretical examinations there will be a recovery of the parts not approved only from the suspended part. The mark of each part is 25% of the final mark.
Assessment Activities
| Title | Weighting | Hours | ECTS | Learning Outcomes |
|---|---|---|---|---|
| Group work | 25% | 6 | 0.24 | 1, 2, 13, 4, 6, 5, 8, 14, 7, 9, 10, 11, 16, 12 |
| partial exams (3) | 25% | 2 | 0.08 | 1, 2, 13, 4, 3, 5, 8, 14, 7, 10, 11, 15, 16, 12 |
Bibliography
Couse textbook:
Development of Sustainable Bioprocesses. (2006). E. HEINZLE, A.P. BIWER, C.L. COONEY. John Wiley & Sons Ltd, UK. ISBN-10 0-470-01559-4
Related texbooks:
Microbial Biotechnology.Fundamentals of Applied Microbiology (2007). Second Edition Alexander N. Glazer and Hiroshi Nikaido. CambridgeUniversity Press. ISBN-13 978-0-511-34136-6
Modern Industrial Microbiology and Biotechnology. (2007). Nduka Okafor. Science Publishers. USA. ISBN 978-1-57808-434-0 (HC)
Industrial Pharmaceutical Biotechnology. Heinrich Klefenz (2002). Wiley-VCH Verlag GmbH. ISBNs: 3-527-29995-5 (HC)
Biopharmaceuticals. Biochemistry and Biotechnology. Second Edition (2003). Gary Walsh. John Wiley & Sons, Inc. UK. ISBN 0 470 84326 8 (ppc)
Pharmaceutical Biotechnology, Drug Discovery and Clinical Applications. O.Kayser and R.H.Muller. (2004). Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. ISBN: 3-527-30554-8
Enzymes in Food Technology. (2002).R.J. Whitehurst and B.A. Law. Sheffield Academic Press Ltd, UK. ISBN 1–84127–223–X
Food Biotechnology. Second Edition (2006). Kalidas Shetty, Gopinadhan Paliyath, Anthony Pometto, Robert E. Levin. CRC Press.Taylor & Francis Group. Boca Raton, FL33487-2742
Wastewater Microbiology. (2005). Gabriel Bitton. Third Edition. John Wiley & Sons, Inc. UK.
WEBs: Fundación Genoma España: http://www.gen-es.org/