Degree | Type | Year | Semester |
---|---|---|---|
2500502 Microbiology | OB | 2 | 1 |
The student must have got the learning competences of the courses programmed during the first course of the Degree. It is highly recommended some formation in Biochemistry, Genetics and Cell Biology.
CONTEXTUALIZATION AND OBJECTVES
Immunology is an obligatory course, specific of the Microbiology degree and included in the Area “Sanitary Microbiology”. Immunology introduces students in the study of physiological and pathological mechanisms of defence and specific response of the organisms against the presence of antigens, as microorganisms and toxins. This course is integrative and students can address the inter-relation between pathogens and hosts from their knowledge acquired in cell biology, microbiology, biochemistry, genetics and animal biology.
Objectives of the course:
The 6 ECTS course of Immunology is split in three blocks with different objectives that the student will have to achieve at the end of the course.
Block I. Basic Immunology
• to know the concepts of innate and specific immunology and to recognize the important role of each of them during the response against pathogens.
• to identify the elements that play a role in both responses.
• to enumerate and explain the structural and functional features of the molecular and cellular components of the innate and adaptive immunity.
• to explain the features of the lymphoid organs and the recirculation of lymphocytes.
Block I. Organization of the Immune Response
• to integrate the elements described in the lessons of the Block I with the three phases of the immune response: 1) activation phase; 2) effector phase; and 3) regulation phase and homeostasis.
• to identify the type of immune responses activated for each infectious agent: bacteria, virus, fung and parasites.
Block III. Immunopathology and Immunotherapy
• to identify the disfunction of the immune system which is the cause of the immunopathologies: hypersensitivity, immunodeficiencies and autoimmunity.
• to analyze the association of an ineficient response against infectious agents and certain immunopathologies.
• to associate the targets of the immune response of different palliative and profilactic treatments.
Each block is divided in teaching units (TU) organized by lessons defining the specific learning descriptors associated to the corresponding competences.
Block I. BASIC IMMUNOLOGY: ELEMENTS OF THE IMMUNE SYSTEM
Lesson 1. Introduction
TU-1. Innate immunity
Lesson 2. Innate immunity
Lesson 3. The complement system
Lesson 4. Cells of the innate immunity
TU-2. Antigen specific receptors, presenting molecules and antigen recognition
Lesson 5. Structure of immunoglobulins
Lesson 6. Organization of the genes of immunoglobulins
Lesson 7. T cell receptor (TCR)
Lesson 8. Structure and function of the Major Histocompatibility Complex (MHC) molecules
Lesson 9. Antigen processing and recognition
Lesson 10. Genetic organization of the MHC
TU-3. Cells of the immune system
Lesson 11. T lymphocytes
Lesson 12. B lymphocytes and antigen presenting cells
TU-4. Organs of the immune system and lymphocyte recirculation
Lesson 13. Organization of the organs of the immune system
Lesson 14. Cytokines and chemokines
Lesson 15. Leukocyte recirculation
Block II. ORGANIZATION OF THE IMMUNE RESPONSE
UD-5. Immune response
Lesson 16. Cellular immune system I
Lesson 17. Cellular immune system II
Lesson 18. Humoral immune system I
Lesson 19. Humoral immune system II
Lesson 20. Regulation of the immune response
UD-6. Immune response against pathogens and mechanisms of action
Lesson 21. Immune response against bacteria, fungs and parasites I
Lesson 22. Immune response against bacteria, fungs and parasites II
Lesson 23. Immune response against virus
Block III. IMMUNOPATHOLOGY AND IMMUNOTHERAPY
UD-7. Immunopathology
Lesson 24. Reactions of hypersensitibity I
Lesson 25. Reactions of hypersensitibity II
Lesson 26. Autoimmunity
Lesson 27. Immunodeficiencies I
Lesson 28. Immunodeficiencies II
Lesson 29. Immunotherapy. Vaccines
Lesson 30. Tumor immunology
“*Unless the requirements enforced by the health authorities demand a prioritization or reduction of these contents.”
Educational activities programmed for the course of Immunology of Microbiology degree are:
- EXPOSITIVE LESSONS
Lessons of the Didactive Units (UD) will be teached in 30 sessions.
- SEMINARS
For the seminars, the group will be split in two subgroups, G1-IMM and G2-IMM, with an estimated number of 30 students per group. A total of 15 sessions per group will be given with the following programmed activities:
Immunology is an experimental science and it is important that the student get the competences required to work in a laboratory. Some techniques based in the antigen-antibody recognition and others used in an Immunology laboratory will be explained.
Exams will include 3-5 questions for the evaluation of these activities (they will be a 10% of the partial qualification, that is, a 7% of the final qualification).
There are programmed 4 sessions to explain the concepts on which these techniques are based and the expected result will be obtained for each:
TE1 and TE2: Techniques based on the antigen-antibody interaction.
TE3 and TE4: Techniques used for the study of T lymphocytes.
Two cases have been programmed. To solve the cases, students must work in groups. The design and pautes of the case will be included in the programmation of the Blocks. Information of the cases will be uploaded by the teacher in the Virtual Campus (CV). In class the students ask the doubts about the case. The teacher will upload the questions in the CV and the students will answer them in groups.
This activity will consist in the oral presentation of a research article. The final objective is to learn to expose clearly a research article (introduction, hypothesis, exposition and interpretation of the results and discussion of them). Four sessions will be done in which students will expose an article with questions
It has been programmed 3 sessions of Seminars by professionals of the field of Immunology and Microbiology. These sessions will serve to consolidate the learning of the theoretical lessons.
“*The proposed teaching methodology may experience some modifications depending on the restrictions to face-to-face activities enforced by health authorities.”
Title | Hours | ECTS | Learning Outcomes |
---|---|---|---|
Type: Directed | |||
Seminars | 15 | 0.6 | 1, 6, 3, 5, 8, 7 |
Theory lessons | 30 | 1.2 | 1, 4, 2, 5, 7 |
Type: Autonomous | |||
Preparation of a research article (bibliographic search, reading, experimental techniques) | 15 | 0.6 | 1, 6, 2, 3, 5, 8, 7 |
Resolution of cases / ABP (bibliographic search and text reading) | 20 | 0.8 | 1, 6, 3, 5, 8, 7 |
Study | 66 | 2.64 | 1, 6, 4, 2, 3, 5, 8, 7 |
Evaluation of the course will be individual and continuous through the next proves:
- Individual learning by parcial exams.
- Cooperative learning through forming activities during the seminar lessons.
The evaluation activities are:
Partial exams: Two partial examns at the end of Blocks I and III. The value of the first partial is 30% and of the second partial 40% of the final qualification. They will consist in test exams with 30 questions, 5 options and one unique correct response. To be evaluated, the student will have to answer at least 70% of the exam (21 questions). Each wrong response will diminish ¼ of the value. Non-answered questions will not have penalization. Three questions about experimental techniques (TE) will be included with a value of 10% of the exam (3% and 4% of the final course qualification, respectively). The duration of the exams will be of 2 hours. To the exams be considered, students must obtain a minimum of 3.5 points (over 10 points, 1.05 over 3) in the first partial and 4 points (over 10 points, 1.6 over 4) in the second exam. The average qualification must be at least of 4 over 10 (2.8 over 7).
Cases (ABP): Cases will be a cooperative work in 4-students groups. They can be practical problems or clinical cases. The objective is to develop auto-learning, synthesis and written communication capacities.
Evaluation will represent 15% (5% for the first case and 10% for the second one) of the final qualification. It will be evaluated as an on line delivery of an autonomous work of the group. Written presentation, answers and own aportation will be considered.
Articles (ART): Articles will be uploaded some weeks befor the exposition. Class sessions will consist in the presentation of the article by the group members and some questions by the teacher.
Evaluation of the oral presentation will represent 15%of the final qualification. Contents, oral exposition, clarity of slides and defense of the issues will be considered.
As the groups will be maintained during the course, the qualification of ABP and ART (30% of the final qualification) will be given to the full group. Students will have to distribute individual qualifications depending individual contribution. The individual qualification must not be higher than 3 points.
Retake exam: A final exam will be programmed for students which could not obtain the minimum to pass the course or for those students which can increase the qualification. The value of the exam will be 70% of the qualification. The exam will consist in 50 test questions (with 5 questions on TE) and only students that have participated in the continuous evaluation proves (partial exams) can access to the final exam. The exam will have a duration of 2 hours.
To pass the course the student must obtain a minimum of 50% after the addition of the values of individual and cooperative work modules. Students that will not obtain a minimum of 40% of the individual work will have access to pass the course in the final exam.
Students which want to increase the qualification must renounce to the obtained qualification during the partial exams and accept the qualification obtained in the final exam.
To be eligible for the retake process, the student should have been previously evaluated in a set of activities equaling at least two thirds of the final score of the course or module. Thus, the student will be graded as "Not Evaluable" if the weighting of all conducted evaluation activities is less than 67% of the final score.
“*Student’s assessment may experience some modifications depending on the restrictions to face-to-face activities enforced by health authorities.”
Title | Weighting | Hours | ECTS | Learning Outcomes |
---|---|---|---|---|
Cases | 15% | 0 | 0 | 1, 6, 3, 5, 8, 7 |
Partial exam 1 | 30% (27% + questions TE 3%) | 2 | 0.08 | 1, 6, 4, 2 |
Partial exam 2 | 40% (36% + questions TE 4%) | 2 | 0.08 | 1, 6, 4, 2 |
Research article | 15% | 0 | 0 | 1, 6, 2, 3, 5, 8, 7 |
BIBLIOGRAPHY
Janeway’s Immunobiology by K Murphy. Ltd/Garland Science, NY & London, 8th ed., (2012).
Kuby Immunology (with web support) by J.A. Owen, J Punt, S. A. Stranford. W.H. Freeman Co., 7th ed, (2013).
Cellular and Molecular Immunology by Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai. Saunders, 8th ed, (2014).
Roitt's Essential Immunology, by Peter Delves, Seamus Martin, Dennis Burton, Ivan Roitt. Wiley-Blackwell Ed., 12th ed., (2011).
Immunology, 7 th Edition by David K. Male, Jonathan Brostoff, Ivan Maurice Roitt, David B. Roth Mosby Elsevier Ed. (2006).
Immunology, Infection and Immunity by Pier GB, Lyczak JB & Wetzler LM. ASM International (2004).
Medical Microbiology and Immunology by Warren Levinson. Lange Medical Books / McGraw-Hill, 10 th ed. (2006).
Review of Medical Microbiology and Immunology by Warren Levinson. Lange Basic Sicence / McGraw - Hill, 11th (2010).
IMMUNOBIOLOGIA: El sistema inmunitario en condiciones de salud y enfermedad de C. Janeway Jr., P. Travers, L. Walport, M. J. Shlomchik. Traducción de la 4ª edición. Editorial Masson, S.A. Barcelona, (2003).
Inmunología Celular y Molecular de A.Abbas, W. Lichtman, R. Pober. W. B. Saunders Co., Philadelphia, 5ª edición, (2004).
Introducción a la Inmunología Humana de L. Faimboim, J. Geffner. Ed Medica Panamericana, 5ª edición (2005).
Kuby Immunology (en español) by T.J. Kindt, R.A. Goldsby, B.A. Osborne. W.H. Freeman Co., 6 th ed, (2007).
Inmunología de P. Parham. Ed. Panamericana, 2ª ed. (2006).
Fundamentos de Inmunología de Roitt,I. M. Panamericana, 10ª ed. (2003).
Inmunología de I. Roitt, J. Brostoff, D. Male. Hartcourt Brace, 5ª ed. (2003).
COMPLEMENTARY BIBLIOGRAPHY.
Advances in Immunology
http://www.elsevier.com/wps/find/bookdescription.cws_home/716912/description#description
http://www.sciencedirect.com/science/bookseries/00652776
Annual Review of Immunology
http://arjournals.annualreviews.org/loi/immunol
Current Opinion in Immunology
http://www.elsevier.com/wps/find/journaldescription.cws_home/601305/description#description
http://www.sciencedirect.com/science/journal/09527915
Journal of Microbiology, Immunology and Infection
http://www.jmii.org/
Microbiology and Immunology
http://www.wiley.com/bw/journal.asp?ref=0385-5600
http://www3.interscience.wiley.com/journal/118503650/home
Nature Reviews in Immunology
http://www.nature.com/nri/index.html
Seminars in Immunology
http://www.elsevier.com/wps/find/journaldescription.cws_home/622945/description#description
Trends in Immunology
http://www.cell.com/trends/immunology/
Trends in Microbiology
http://www.cell.com/trends/microbiology/
Immunobiology by C. A. Janeway, P. Travers, M. Walport and M. Shlomchik. Garland Science2001
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=imm
Roitt's Essential Immunology, by Peter Delves, Seamus Martin, Dennis Burton, Ivan Roitt. Wiley-Blackwell Ed., 11 th ed., (2006).
http://www.roitt.com/
Kuby Immunology (with web support) by T.J. Kindt, R.A. Goldsby, B.A. Osborne. W.H. Freeman Co., 6 th ed, (2006).
http://www.whfreeman.com/kuby/
http://bcs.whfreeman.com/immunology6e/
Microbiology and Immunology On line. School of Medicine, University of South Carolina
http://pathmicro.med.sc.edu/book/welcome.htm
Faculty of Medicine, Dalhouse University (Halifax, Nova Scotia, Canada)
http://immunology.medicine.dal.ca/bookcase/
The Infectious Diseases WebLink
http://webpages.charter.net/deziel/
Immunobiology
http://www.skidmore.edu/academics/biology/courses/erubenst/BI348/pages/resources.html
Janeway's animations (també en podeu trobar d'animacions del llibre Janeway's Immunology a la web del yooutube)
http://www.blink.biz/immunoanimations/