This version of the course guide is provisional until the period for editing the new course guides ends.

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Cell Biology

Code: 102954 ECTS Credits: 6
2025/2026
Degree Type Year
Medicine FB 1

Contact

Name:
Maria Oliver Bonet
Email:
maria.oliver@uab.cat

Teachers

Jordi Ribas Maynou
Marina Rodriguez Muņoz
Maria Oliver Bonet
Montserrat Codina Pascual
Itziar Salaverria Frigola
Alejandro Gella Concustell
Maria Terradas Ill

Teaching groups languages

You can view this information at the end of this document.


Prerequisites

There are no prerequisites for taking the core subject of Cell Biology as it is a subject in the first semester of the first year. However, in order to ensure proper follow-up and the achievement of the learning objectives set out, it is recommended that students have a basic general knowledge of the structure, chemical composition and functions of the cells.

In addition, students should have good knowledge of English because many of the sources of information on this subject are in this language.


Objectives and Contextualisation

The subject of Cell Biology aims to provide students with a solid understanding of the fundamental principles of the organization and functioning of the cell. It also aims to establish clear links between this knowledge and the processes that contribute both to the maintenance of health status and to the development of diseases in human beings.

At the end of the course, the student should be able to:

  • Explain the general characteristics of eukaryotic cells and understand their role as the basic functional unit of the tissues and organs of the human body.
  • Describe the structure, composition and functions of cell membranes; to analyse the mechanisms of transport of molecules across membranes and to interpret how their alterations can lead to cellular disorders that lead to diseases (cystic fibrosis), or in drug resistance mechanisms 
  • To characterize the elements of the cell surface involved in intercellular communication, cell recognition and adhesion, and their relationship with processes such as metastasis or immunodeficiencies
  • Describe the composition and functions of the cytosol and its involvement in cellular metabolic regulation.
  • Explain the structure and function of cell organelles, both in the internal membranous system and in mitochondria and peroxisomes, and understand how their dysfunction can affect cell physiology and the development of diseases associated with their malfunction.
  • Explain the molecular mechanisms of programmed cell death (apoptosis) and its importance in embryonic development and the pathologies associated with its dysfunction.
  • Identify the components of the cytoskeleton and explain their role in cellular processes such as division, motility, migration and intracellular transport, as well as the implications of their alteration in neuromuscular or cancerous diseases.
  • Analyse the structure and function of the nuclear envelope and understand its relationship with the regulation ofgene expression and certain genetic pathologies.
  • Describe the organization of chromatin and the processes of replication and transcription, integrating them into the understanding of diseases of genetic or epigenetic origin.
  • Describe the main mechanisms of cell signaling, recognize the components of signal transduction pathways and understand how their alteration can contribute to the development of pathologies such as cancer, diabetes or autoimmune diseases
  • Identify the main control points of the cell cycle and the molecules involved in its regulation, as well as understand their role in tissue physiology and cancer genesis.
  • List and describe the different phases of mitotic and meiotic cell division, establishing comparisons between them and their relevance in processes such as growth, regeneration and reproduction.
  • Describe the processes of male and female gametogenesis, and understand how alterations in these processes can have an impact on fertility.
  • Explain the process of fertilization, integrating the cellular elements involved and the possible causes of reproductive failure.
  • Describe the characteristics and potential of stem cells, as well as their involvement in tissue regeneration and regenerative medicine.
  • Understand the phenomenon of cellular senescence, its role in ageing and its relationship with degenerative diseases and cancer.
  • Rigorously use the scientific terminology of the field of cell biology to communicate concepts clearly and precisely in academic and professional contexts.

Competences

  • Communicate clearly, orally and in writing, with other professionals and the media.
  • Convey knowledge and techniques to professionals working in other fields.
  • Critically assess and use clinical and biomedical information sources to obtain, organise, interpret and present information on science and health.
  • Demonstrate basic research skills.
  • Demonstrate knowledge of the principles and physical, biochemical and biological processes that help to understand the functioning of the organism and its disorders.
  • Demonstrate understanding of the basic sciences and the principles underpinning them.
  • Demonstrate understanding of the importance and the limitations of scientific thought to the study, prevention and management of diseases.
  • Demonstrate understanding of the mechanisms of alterations to the structure and function of the systems of the organism in illness.
  • Demonstrate understanding of the organisation and functions of the genome, the mechanisms of transmission and expression of genetic information and the molecular and cellular bases of genetic analysis.
  • Demonstrate understanding of the structure and function of the body systems of the normal human organism at different stages in life and in both sexes.
  • Formulate hypotheses and compile and critically assess information for problem-solving, using the scientific method.
  • Maintain and sharpen one's professional competence, in particular by independently learning new material and techniques and by focusing on quality.
  • Recognise the effects of growth, development and ageing on individuals and their social environment.

Learning Outcomes

  1. Communicate clearly, orally and in writing, with other professionals and the media.
  2. Convey knowledge and techniques to professionals working in other fields.
  3. Demonstrate basic research skills.
  4. Describe the functional and organisational structure of hereditary nuclear and mitochondrial material.
  5. Describe the processes involved in somatic and germinal cell proliferation: mitosis and meiosis.
  6. Describe the processes of cell differentiation, ageing and death.
  7. Explain how alterations to cell components lead to structural and functional alterations to systems of the human organism.
  8. Explain the molecular and cellular significance of tissue and system structure.
  9. Formulate hypotheses and compile and critically assess information for problem-solving, using the scientific method.
  10. Identify the basic functional and organisational structure of hereditary nuclear and mitochondrial material.
  11. Identify the basic processes of life on various levels of organisation: cell, organ and individual.
  12. Identify the cell processes that can be the cause or the consequence of pathological manifestations in the organism.
  13. Identify the main cellular processes involved in growth, development and ageing in individuals and their social environment.
  14. Identify the mechanisms and the molecular and cellular processes that can be the cause or the consequence of pathological manifestations in the organism.
  15. Integrate the functions of the the different cell organelles and structures with the overall functioning of the cell.
  16. Maintain and sharpen one's professional competence, in particular by independently learning new material and techniques and by focusing on quality.
  17. Relate the structure of the different parts of cell to its functioning.
  18. Use specific bibliographic sources in cell biology to work independently on acquiring further knowledge.

Content

La cèl·lula eucariota; membrana plasmàtica; transport a través de membrana; citosol; sistema membranós intern; transport vesicular; orgànuls de conversió energètica; mort cel·lular programada (apoptosi); citoesquelet; matriu extracel·lular; nucli i la seva relació amb el citoplasma;  senyalització cel·lular; cicle cel·lular i el seu control; divisió cel·lular: mitosi i meiosi; gametogènesi masculina i femenina; fecundació; cèl·lules mare; senescència

Blocs distributius

A. Característiques generals de les cèl·lules eucariotes:  nivells d’organització cel·lular i introducció a la compartimentació cel·lular i al trànsit de vesícules.

B. Membrana plasmàtica. Organització macromolecular de la membrana plasmàtica i glicocàlix. Característiques de la membrana: fluïdesa i asimetria.

C. Citosol: composició i funcions. Sistema membranós intern. Elements del sistema membranós intern. Estructura i funcions del reticle endoplasmàtic rugós i llis i de l’aparell de Golgi, dels

D. Transport de molècules: transport d’ions, petites molècules, macromolècules i partícules. Processos d'endocitosi, pinocitosi, potocitosi, fagocitosi i exocitosi. Endosomes i lisosomes

E. Mitocondris i peroxisomes: estructura i composició. Funcions del mitocondri i del peroxisoma. Biogènesi. Genoma mitocondrial. Importació de proteïnes i lípids del citosol. Apoptosis. Alteració de la funció mitocondrial en càncer.

F. Citoesquelet. Components del citoesquelet: Estructura i Funcions. Proteïnes associades al citoesquelet: exemples iassociació amb malaltia. Tipus de filaments intermedis i la presència segons tipus cel·lulars.

G. Adhesió cel·lular i matriu. Molècules d’adhesió i d'unió cel·lular. Estructura i funcions i dels diferents tipus d’unions: oclusives, d’ancoratge, adhesives cèl·lula-cèl·lula, adhesives cèl·lula-matriu extracel·lular, i comunicants. Exemples de relació matriu i cèl·lula: extravasació limfocitària; metàstasi. 

H. Nucli i activitat nuclear. Estructura dels seus components: embolcall nuclear, porus nuclear, làmina nuclear, matriu nuclear, nuclèol, nucleoplasma. Estructura i organització de la cromatina: relació amb la lamina nuclear i amb el control genètic de la transcripció. RNAs no codificants: tipus, biogènesi, estructura i funció.  RNAs no codificants i càncer.

I. Senyalització cel·lular. Característiques generals. Receptors, factors de creixement i proteïnes associades.

J. Cicle cel·lular: fases i mecanismes de control. Divisió cel·lular mitòtica: fases. Alteracions del cicle i el seu control: senescència, immortalitat i càncer.

K. Meiosi. Divisions meiòtiques: fases. Significat biològic de la meiosi: diversitat genètica i recombinació meiòtica. Gametogènesi masculina. Gametogènesi femenina. Mecanisme de fecundació. Cèl·lules mare.


Activities and Methodology

Title Hours ECTS Learning Outcomes
Type: Directed      
THEORY (TE) / CLASSICAL PRACTICES (PAUL) / LABORATORY PRACTICES (PLAB) / SPECIALIZED SEMINARS (SESP) 53 2.12 1, 3, 6, 5, 4, 2, 8, 7, 9, 14, 13, 11, 12, 10, 15, 16, 17, 18
Type: Supervised      
PROBLEM-BASED LEARNING (ABP) 23 0.92 1, 3, 6, 5, 4, 2, 8, 7, 9, 14, 13, 11, 12, 10, 15, 16, 17, 18
Type: Autonomous      
DEVELOPMENT OF WORK / PERSONAL STUDY 69 2.76 1, 3, 6, 5, 4, 2, 8, 7, 9, 14, 13, 11, 12, 10, 15, 16, 17, 18

Directed Teaching
Theory lecture (TE). Classroom practices (PAUL). Laboratory practices (PLAB). Specialized seminars (SEM)

Supervised Teaching

Problem based learning

Autonomous Teaching
Personal study. Elaboration of works

Annotation: Within the schedule set by the centre or degree programme, 15 minutes of one class will be reserved for students to evaluate their lecturers and their courses or modules through questionnaires.


Assessment

Continous Assessment Activities

Title Weighting Hours ECTS Learning Outcomes
Classroom practices: evaluations written through objective tests of multiple choice items 10% 1 0.04 1, 3, 5, 2, 9, 13, 12, 15, 16, 17
Laboratory practices y seminario: written assessments through activities or test essays of restricted questions and objective tests of multiple choice items 20% 1 0.04 6, 5, 9, 14, 13, 12, 15, 16, 17, 18
Theory: evaluations written through objective tests: multiple choice items 70% 3 0.12 6, 5, 4, 8, 7, 14, 13, 11, 12, 10, 15, 17

Evaluation Model

The evaluation of the subject will be based on the theoretical and practical syllabus that consists in the Program of the same. The achievement of the objectives and the acquisition of the competences described in the previous sections will be assessed, both those associated with the theoretical concepts expressed in the blocks and those associated with seminars and practices (laboratory and classroom).

Continuous evaluation:

The subject will be evaluated continuously during the course through two partial tests (P1 and  P2) eliminatory of subject plus three activities or tests that will evaluate the content of the  sessions of laboratory practices (S1, S2, S3), and a test that will evaluate the  contents of the microscopy seminar (SEM). Each of the two partial tests will be done through an objective exam with multiple choice items, aimed at demonstrating the acquisition of competences and the integration of theoretical and practical learning. It will consist of multiple choice questions with 4 answers, of which 1, 2 or 3 can be true. Wrong answers will be proportionately subtracted.

The contents that will be evaluated in P1 are: i) Theory of the first topics (from A to D ) (32%) and ii) the first two classroom practices (5%)

The contents that will be evaluated in P2 are: i) Theory of the last topics (from E to K) (38%) and ii) classroom practices 3 and 4 (5%).

The tests or activities that will be carried out in the S1, S2 and S3 of laboratory practices and in the SEM will evaluate the participation and knowledge acquired in each of these sessions. The activities or tests will be related to the activity carried out.

The partial tests P1 and P2 will be done on the days indicated by the Faculty, in the classrooms indicated. The activities or tests of S1, S2, S3 and SEM will be done in the same practice laboratory (for S1, S2 and S3) or in the seminar room (for SEM), at the end of each of the sessions and are not recoverable. Each of the tests and activities described in the previous paragraph will have the following weighting in the final grade of the subject:

P1 (37%) + P2 (43%) + S1(5%) + S2 (5%) + S3 (5%) + SEM (5%)

To pass the subject, the following requirements must be met: i) that the two grades obtained in P1  and  P2 are  equal  to  or greater than 5  and ii) that the weighted average of P1+P2+S1+S2+S3+SEM is equal to  or greater than5 out of 10.

Attention: attendance at laboratory practice sessions is mandatory for students enrolled for the first time in this subject and who follow the continuous assessment model. Repeating students of previous courses who have a grade higher than 5 in tests S1, S2 and S3 are not obliged to do them and the mark obtained the previous course is saved.

Final test of recovery:

In the case of not passing the subject through continuous assessment, there will be a final evaluation of recovery of the partial tests with a grade lower than 5, mandatory to make average. Students with partial tests with a grade greater than 5 can also take the recovery exam in order to try to raise the grade of the partial or partials they consider. To do this, they must request it sufficiently in advance from the coordinator of the subject. The grade previously obtained in the continuous evaluation will be replaced by the grade obtained in the recovery exam

In order to participate in the recovery test, two requirements must be met: i) have submitted to the two partial tests P1 and P2  and ii) that  the weighted average mark of the continuous evaluation (P1(37%)+P2(48%)+S1(5%)+S2 (5%)+S3 (5%)+SEM(5%)) is equal to or greater than 2.5.

The recovery exam will consist of two parts:

The first part (37% of the final grade) is an objective test that corresponds to the contents of P1, and therefore evaluates the following contents: i) Theory of the first topics (from A to D) (32%) and ii) the first two classroom practices (5%).

The second part (48% of the final grade) is an objective test that corresponds to the contents of P2, and therefore evaluates the following contents: i) Theory (38%) of the last topics (from E to K) and ii) classroom practices 3 and 4 (5%).

Students who have passed one of the two partials with a grade equal to or greater than 5 will be able to examine only the corresponding part of the suspended partial, without also having to submit to the partial that they have already approved.

The final grade of recovery of the subject will be  the sum of the weighted grade of the recovery exam plus the weighted notes of the two practice tests. In case a student has passed a partial, the grade obtained during the continuous assessment, corresponding weighted, will be taken into account for the calculation of the final grade of the recovery exam.

The day and time of the revisions of the partial exams and the recovery exam will be announced immediately upon the publication of the notes.

Exam review procedure:

Students may submit claims to the statement of the questions during the two days following the completion of the face-to-face exams.

The day and time of the revisions of the partial exams and the recovery exam will be announced immediately upon the publication of the notes.

 

ATTENTION: Student's assessment may experience some modifications depending on events outside the universitythat may affect face-to-face learning.

 

Examination-based evaluation:

Students can enter the single assessment system, according to the regulations of the Faculty. Single assessment will be based on the content of the subject's programme, the acquisition of the same competences, and will have the same level of demand as continuous assessment.

Single assessment consists of examinations carried out on the same date as the second partial of the continuous assessment.

For the evaluation an exam will be carried out consisting of:

Theoretical knowledge

- multiple choice questions to evaluate the theoretical knowledge of the subject (blocks A-K) and the content of the PAUL, with a weighting of 80% of the overall grade.

Practical knowledge

- Multiple choice questions and / or restricted written questions of the concepts related to the laboratory and seminar practices, with a weighting of 20% of the overall grade.

To pass the subject, the following requirements must be met:

1. Have obtained a grade of 5.0 or higher in the exam that evaluates the theoretical knowledge of the subject.

2. That the weighted average of the marks obtained in the different exams carried out is equal to or greater than 5.0.

The student who does not attend the scheduled global and recovery exams will be considered as "not evaluable".


Retake exam. The same recovery system will be applied as for continuous assessment.

The review of the qualifications will follow the same procedure as for the continuous assessment.


Bibliography

BASIC BIBLIOGRAPHY 

1 - "Biología Molecular de la Célula". Alberts y col. 6ª edición. Ed. Omega. Barcelona, 2016

2 - "Molecular Biology of the Cell". Alberts et al. 7th edition. W W Norton&Company. New York, 2022

3 - "La Célula". Cooper y Hausman. 7ª edición. Ed. Marbán Libros S.L. Madrid, 2017

4 - "The Cell". Cooper & Hausman 7th edition, Sinauer Associetes (Oxford University Press), 2017

5 - "Introducción a la Biología Celular". Alberts y col. 3ª ed. Ed. Médica Panamericana. Madrid, 2010

6 - "Biología Celular Biomédica" Calvo A. Elsevier. Barcelona, 2015

7 - "Biología Celular y Molecular". Karp. 6ª edició. Ed. Mac Graw-Hill Interamericana S.A. Mèxic, 2011
 
8 - "Molecular Cell Biology". Lodish et al. 8th edition. WH Freeman and Company. New York, 2016

9 - "The World of the Cell". Becker et al. 7th edition. Pearson. San Francisco, 2008

 

INTERNET RESOURCES

 - Books: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books

 - Open access review articles and accessible review articles from the computers of the UAB Network. (If you are outside the campus, through the ARE service, Access to Electronic Resources service)


Software

There is no need for any specific software


Groups and Languages

Please note that this information is provisional until 30 November 2025. You can check it through this link. To consult the language you will need to enter the CODE of the subject.

Name Group Language Semester Turn
(PAUL) Classroom practices 101 Catalan first semester morning-mixed
(PAUL) Classroom practices 102 Catalan first semester morning-mixed
(PAUL) Classroom practices 103 Catalan first semester morning-mixed
(PAUL) Classroom practices 104 Catalan first semester morning-mixed
(PAUL) Classroom practices 105 Catalan first semester morning-mixed
(PAUL) Classroom practices 106 Catalan first semester morning-mixed
(PAUL) Classroom practices 107 Catalan first semester morning-mixed
(PAUL) Classroom practices 108 Catalan first semester morning-mixed
(PAUL) Classroom practices 109 Catalan first semester morning-mixed
(PAUL) Classroom practices 110 Catalan first semester morning-mixed
(PLAB) Practical laboratories 101 Catalan first semester morning-mixed
(PLAB) Practical laboratories 102 Catalan first semester morning-mixed
(PLAB) Practical laboratories 103 Catalan first semester morning-mixed
(PLAB) Practical laboratories 104 Catalan first semester morning-mixed
(PLAB) Practical laboratories 105 Catalan first semester morning-mixed
(PLAB) Practical laboratories 106 Catalan first semester morning-mixed
(PLAB) Practical laboratories 107 Catalan first semester morning-mixed
(PLAB) Practical laboratories 108 Catalan first semester morning-mixed
(PLAB) Practical laboratories 109 Catalan first semester morning-mixed
(PLAB) Practical laboratories 110 Catalan first semester morning-mixed
(PLAB) Practical laboratories 111 Catalan first semester morning-mixed
(PLAB) Practical laboratories 112 Catalan first semester morning-mixed
(PLAB) Practical laboratories 113 Catalan first semester morning-mixed
(PLAB) Practical laboratories 114 Catalan first semester morning-mixed
(PLAB) Practical laboratories 115 Catalan first semester morning-mixed
(PLAB) Practical laboratories 116 Catalan first semester morning-mixed
(PLAB) Practical laboratories 117 Catalan first semester morning-mixed
(PLAB) Practical laboratories 118 Catalan first semester morning-mixed
(PLAB) Practical laboratories 119 Catalan first semester morning-mixed
(PLAB) Practical laboratories 120 Catalan first semester morning-mixed
(SEM) Seminars 101 Catalan first semester morning-mixed
(SEM) Seminars 102 Catalan first semester morning-mixed
(SEM) Seminars 103 Catalan first semester morning-mixed
(SEM) Seminars 104 Catalan first semester morning-mixed
(SEM) Seminars 105 Catalan first semester morning-mixed
(SEM) Seminars 106 Catalan first semester morning-mixed
(SEM) Seminars 107 Catalan first semester morning-mixed
(SEM) Seminars 108 Catalan first semester morning-mixed
(SEM) Seminars 109 Catalan first semester morning-mixed
(SEM) Seminars 110 Catalan first semester morning-mixed
(SEM) Seminars 111 Catalan first semester morning-mixed
(SEM) Seminars 112 Catalan first semester morning-mixed
(SEM) Seminars 113 Catalan first semester morning-mixed
(SEM) Seminars 114 Catalan first semester morning-mixed
(SEM) Seminars 115 Catalan first semester morning-mixed
(SEM) Seminars 116 Catalan first semester morning-mixed
(SEM) Seminars 117 Catalan first semester morning-mixed
(SEM) Seminars 118 Catalan first semester morning-mixed
(SEM) Seminars 119 Catalan first semester morning-mixed
(SEM) Seminars 120 Catalan first semester morning-mixed
(TE) Theory 101 Catalan first semester afternoon
(TE) Theory 102 Catalan first semester afternoon
(TE) Theory 103 Catalan first semester afternoon
(TE) Theory 104 Catalan first semester afternoon