Degree | Type | Year |
---|---|---|
4313792 Neurosciences | OB | 0 |
You can view this information at the end of this document.
The requirements are those for access to the master’s program. It is necessary to have a sufficient level of English for classes taught in this language.
The general objective is to understand the basic cellular, structural and anatomical characteristics of the Central and Peripheral Nervous System that will allow students to understand research in neuroscience and provide the basis for understanding the pathologies affecting this system.
THEORY AND PRACTICAL SKILLS
DEVELOPMENT OF THE NERVOUS SYSTEM (Alfonso Rodríguez-Baeza)
Zygote, Morula and Blastula. Gastrulation. Primary and secondary neurulation. Spinal cord formation. Early vesicles and flexures: Rhombencephalon, Mesencephalon and Prosencephalon. Secondary vesicles and derivatives: Myelencephalon, Metencephalon, Mesencephalon, Diencephalon and Telencephalon. Cerebral cortex formation. Basal nuclei formation. Hippocampal formation. Neural crest and derivatives. Ectodermal placodes. Peripheral nervous system formation: spinal and cranial nerves. Autonomic nervous system formation. Overview of the sense organs formation. The perinatal nervous system.
CELLULAR NEUROBIOLOGY (Beatriz Almolda Ardid)
Cytology of neurons. Neuronal cytoskeleton: mechanisms of axonal transport. Dendritic arborisation and synaptic terminals. Astrocytes: metabolism, cytoskeleton, function and cell subtypes. Structure and function of blood-brain barrier. Microglia: metabolism, functions and cell types. Radial glia: Characteristics and functions. Ependymocytes and tanycytes: localization, characteristics and functions. PNS satellite glia. Myelination: oligodendrocytes and Schwann cells. CNS and PNS myelination. Molecular structure of myelin. Paranode and fissures. Ranvier node in CNS and PNS. Glia-glia and neuron-glia communication: contact and soluble signalling factors.
NEUROGENESIS AND GLIOGENESIS (Joaquim Martí Clua)
Prenatal, perinatal, and postnatal neurogenesis. Timetables of neurogenesis. Use of tritiated thymidine and bromodeoxyuridine. Migration and neuronal fate: involvement of the radial glia. Convergent and divergent migrations. Neurogenetic gradients. Glia cells generation. Stem cells, progeny, and final location. Origin of the adult stem cells: radial glia cells. Neurogenetic regions in the adult brain: glial and neuron production. Animal models and human studies. Neural stemcells and cancer stem cells. Origin and development of the brain cancers.
NEUROANATOMY (Alfonso Rodríguez-Baeza).
Introduction to the anatomical organization of the CNS. Overview of the brain: lateral, vertical and basal aspects. Overview of the skull and cranial meninges organization. Cerebrum: cerebral hemispheres, basal ganglia and diencephalon. Brain stem: medulla oblongata, pons and midbrain. Cerebellum. Reticular formation. Spinal cord: morphology and overview spinal nerves systematization. Overview of the spine and spinal meninges organization. Ventricular system and cerebrospinal fluid circulation. Cranial nerves: nuclei of origin, pathway and overview of the peripheral distribution. Overview of the special senses: olfaction, vision, taste, hearing and balance. Overview of the autonomic nervous system: sympathetic and parasympathetic. Overview of the ascending and descending pathways. CNS vascularisation: arteries and veins. Basic notions of comparative neuroanatomy.
NEUROHISTOLOGY (Beatriz Almolda Ardid)
Basic structure of nervous tissue. Microscopic structure of peripheral nerve and ganglia. Spinal cord: organization of grey and white matter. Cerebellum: Organization of grey and white matter. Cortical citoarchitecture. Brain. Neocortex. Cytoarchitecture of neocortical layers. Brain. Limbic system. Hippocampal cytoarchitecture. Ventricles and choroid plexus. Meninges: organization and structure. Basic techniques for the histologic study of the nervous system.
PRACTICAL SESSIONS IN LAB
Neurohistology Laboratory (Beatriz Almolda Ardid)
Analysis of microscopic slides using histological and immunohistochemical techniques. Study of specific cellular markers in neuropathological tissues (Alzheimer's disease, Multiple Sclerosis, etc.).
Performing immunocytochemical staining in mixed glia cell cultures (astrocytes, oligodendrocytes, andmicroglia) and/or mouse or rat brain tissues to determine different neural subpopulations (from undifferentiated to mature cells).
Dissection Room (Alfonso Rodríguez-Baeza and Marisa Ortega Sánchez)
Observation of anatomical structures in preparations and topographic sections of the human nervous system.
Title | Hours | ECTS | Learning Outcomes |
---|---|---|---|
Type: Directed | |||
Cellular Neurobiology, Neurogenesis and Gliogenesis, and Neurohistology | 26 | 1.04 | CA01, CA02, CA03, KA02, KA03, SA01, SA02, SA03, CA01 |
Neuroanatomy and development of Nervous System | 26 | 1.04 | CA01, CA03, KA01, KA03, SA01, SA02, CA01 |
Type: Supervised | |||
On line activities and tutorials | 50 | 2 | CA03, KA01, KA02, KA03, SA01, CA03 |
Type: Autonomous | |||
Personal study, comprehension and reading articles, conceptual assimilation of contents | 113 | 4.52 | CA01, CA03, KA01, KA02, KA03, SA01, SA02, CA01 |
GUIDED ACTIVITIES:
THEORETICAL CLASSES (typology TE) Teaching of an essentially expository nature that is usually carried out in a classroom at a pre-scheduled time. The student acquires the knowledge of the module by attending theory classes and supplementing them with personal study of the topics taught.
LABORATORY PRACTICES (typology PLAB) An activity that involves carrying out practical work that requires the student to use specific infrastructure (dissection room, Histology laboratory). They are performed in a specially equipped location, at a specific time, and with the continuous assistance of the teaching staff. They are scheduled at specific times and spaces. For the dissection room practices of the Faculty of Medicine, it is MANDATORY to wear a lab coat and gloves, and it is not allowed to take photographs and/or videos in the dissection room. A certificate that authorizes them to carry out the practices in the dissection room must be available.
SUPERVISED ACTIVITIES:
ON-LINE ACTIVITIES AND TUTORIALS: Teaching taught without classroom attendance and intensively using information and communication technologies (ICT). Students have complementary teaching material for the different training activities through the UAB Campus Virtual, and personal tutorials with the teacher (upon request).
AUTONOMOUS ACTIVITIES:
Comprehension and reading articles. Personal study, implementation of schemes and summaries, conceptual assimilation of the course content.
Annotation: Within the schedule set by the centre or degree programme, 15 minutes of one class will be reserved for students to evaluate their lecturers and their courses or modules through questionnaires.
Title | Weighting | Hours | ECTS | Learning Outcomes |
---|---|---|---|---|
Continues evaluation | 10% | 4 | 0.16 | CA01, CA03, KA01, KA02 |
Evaluation of Lab practices (Anatomy and Histology) | 10% | 2 | 0.08 | CA01, CA02, CA03, KA02, SA02, SA03 |
Objective written evaluation of Anatomy contents | 40% | 2 | 0.08 | CA01, CA03, KA01, KA03, SA01, SA02 |
Objective written evaluation of Histology contents | 28% | 1.5 | 0.06 | CA01, CA02, CA03, KA02, KA03, SA01, SA02 |
Objective written evaluation of Neurogenesis contents | 12% | 0.5 | 0.02 | CA01, CA02, CA03, KA02, KA03, SA01, SA02 |
Evaluation of the module
The module competencies will be evaluated through different activities:
To apply these weightings, it is necessary:
To pass the module, a grade of 5.0 or higher must be obtained once the percentages and requirements have been applied.
Students who have not passed the module will have the possibility to take a recovery exam that will consist of:
The continuous assessment, as well as the objective structured evaluation of the laboratory practices of Anatomy and/or Histology, by their very nature, are NOT recoverable.
In order to take the recovery exam, students must have been previously assessed in a set of activities whose weight is equivalent to at least two-thirds of the total grade for the subject or module. Students will receive a grade of "Not Evaluated" when the completed assessment activities account for less than a third of the final grade.
The single assessment system is not planned in this module.
BIBLIOGRAPHY
Anastasi, G., Gaudio, E., TACCHETTI, C. (Alfonso Rodríguez Baeza editor edición en español) (2022) Anatomía humana - atlas – 2ª ed. Ed. Edra edi-ermes
Carlson, B.M. (2019) Embriología humana y Biología del Desarrollo. 6ª ed. Ed. Elsevier. Accés restringit als usuaris de la UAB. Cal registrar-se prèviament https://www.clinicalkey.com/student/content/toc/3-s2.0-C20180056236
Crossman, AR., Neary, D. (2019) Neuroanatomía: Texto y Atlas en color. 6ª ed. Ed. Elsevier. Accés restringit als usuaris de la UAB. Cal registrar-se prèviament https://www.clinicalkey.com/student/content/toc/3-s2.0-C2019000684X
Dauber, W. (2021) Feneis Nomenclatura Anatómica Ilustrada. 11ª ed. Ed. Elsevier.
Felten, DL., O’Banion, MK., Maida, ME. (2016) Netter Atlas de Neurociencia. 3ª ed. Ed. Elsevier. Accés restringit als usuaris de la UB, UAB, UPC, UPF, UdG, UdL, URV, UVic-UCC i UJI https://www.sciencedirect.com/science/book/9780323265119
Haines, D.E., Mihailoff, G.A. (2019) Principios de Neurociencia. Aplicaciones básicas y clínicas. 5ª ed. Ed. Elsevier. Accés restringit als usuaris de la UAB. Cal registrar-se prèviament https://www.clinicalkey.com/student/content/toc/3-s2.0-C20170037795
Haines, DE. (2021) Neuroanatomía clínica. Texto y Atlas. 10ª ed. Ed. Wolters Kluver. Accés restringit als usuaris de la UB i UAB https://cienciasbasicas.lwwhealthlibrary.com/book.aspx?bookid=2873
Hussain G, Akram R, Anwar H, Sajid F, Iman T, Han HS, Raza C, De Aguilar JG. Adult neurogenesis: a real hope or a delusion? Neural Regen Res. 2024 Jan;19(1):6-15. doi: 10.4103/1673-5374.375317.
Junqueira, L.C., Carneiro, J. (2022) Histología Básica. 13ª ed. Ed. Médica Panamericana.
Kandel, E.R., Koester, J.D.; Mack, S.H. Siegelbaum, S.A. (2021) Principles of Neural Science. 6th ed. Ed. McGraw Hill. Accés restringit als usuaris de la UAB http://lib.myilibrary.com/?id=396874
Li Y, Xu NN, Hao ZZ, Liu S. Adult neurogenesis in the primate hippocampus. Zool Res. 2023 Mar 18;44(2):315-322. doi: 10.24272/j.issn.2095-8137.2022.399. PMID: 36785898; PMCID: PMC10083228.
Mai, J.K., Paxinos, G. (2011) The Human Nervous System. 3rd ed. Ed. Elsevier. Accés restringit als usuaris de la UAB http://lib.myilibrary.com/Open.aspx?id=334767
Matthews G.G. (2000) Neurobiology. Molecules, Cells and Systems. 2nd ed. Ed. John Willey & Sons.
Moore, KL., Persaud, TVN., Torchia, MG. (2019) The Developing Human. Clinically Oriented Embryology. 11ª ed. Ed. Elsevier.
Mtui, E., Gruener, G., Dockery, P. (2017) Fitzgerald. Neuroanatomía Clínica y Neurociencia. 7ª ed. Ed. Elsevier.
Pawlina, W. (2020) Ross. Histología: Texto y atlas. 8ª ed. Ed. Wolters Kluwer.
Purves, D., Augustine, G.J., Fitzpatrick, D, et al (2018) Neuroscience. 6th ed. Ed. Oxford University Press. Accés restringit als usuaris de la UAB http://www.medicapanamericana.com/VisorEbookV2/Ebook/9788498359831
Sadler, TW. (2019) Langman. Embriología Médica. 14ª ed. Ed. Wolters Kluver. Accés restringit als usuaris dela UB i UAB https://cienciasbasicas.lwwhealthlibrary.com/book.aspx?bookid=2899
Simard S, Matosin N, Mechawar N. Adult Hippocampal Neurogenesis in the Human Brain: Updates, Challenges, and Perspectives. The Neuroscientist. 2024;0(0). doi:10.1177/10738584241252581
Splittgerber, R. (2019) Snell Neuroanatomía clínica. 8ª ed. Ed. Wolters Kluver.
Squire, L.R., Berg, D., Bloom, F.E. et al. (2012) Fundamental Neuroscience. 4th ed. Ed. Elsevier.
Standring, S. (2020) Gray’s Anatomy: The Anatomical Basis of Clinical Practice. 42th ed. Ed. Elsevier.
ten Donkelaar, H.J.; Kachlik, D.; Tubss, R.S. (2018) An Ilustrated Terminologia Neuroanatomica. A Concise Encyclopedia of Human Neuroanatomy. 1st ed. Ed. Springe
Vanderah, TH., Gould DJ. (2020) Nolte’s the Human Brain. An introduction to its functional Anatomy. 8ª ed. Ed. Elsevier. Accés restringit als usuaris de la UAB https://ebookcentral.proquest.com/lib/UAB/detail.action?docID=2036217
Waxman, SG. (2007) Molecular Neurology. 1st ed. Ed. Elsevier. Accés restringit als usuaris de UB, UAB https://www.sciencedirect.com/science/book/9780123695093
Access to the mòdule by the UAB Campus Virtual
The library's website can be consulted for "on line" bibliography
Is not necessary specific software
Name | Group | Language | Semester | Turn |
---|---|---|---|---|
(PLABm) Practical laboratories (master) | 1 | Catalan/Spanish | first semester | morning-mixed |
(PLABm) Practical laboratories (master) | 2 | Catalan/Spanish | first semester | morning-mixed |
(TEm) Theory (master) | 1 | Spanish | first semester | morning-mixed |