Degree | Type | Year |
---|---|---|
4313385 Industrial Chemistry and Introduction to Chemical Research | OT | 0 |
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The students involved in this module should have background in chemistry (Analytical Chemistry, Physical Chemistry, Inorganic Chemistry and Organic Chemistry), as well as knowledge in Mathematics, Physics and Biology. Students should also have skills in management of common office applications, possess the English knowledge necessary for understanding lectures, scientific texts, documents, seminars and conferences. Graduates in Chemistry, Chemical Engineering, Materials Science, Nanoscience, Environmental Sciences, Biotechnology, Biochemistry have enough background to take part of this module.
Advanced level of English (level B1) of the Common European Framework Reference for Languages of the European Council is required.
The role of bioanalytical, bioorganic and bioinorganic chemistry in genomics, proteomics, metabolomics and medicine.
- Applying basic concepts of chemistry in biological systems in the field of human health, environmental control, food safety and biotechnology industry.
- Integrating bio recognition and biological reactions in chemical methodology.
- Handling the most common techniques in chemistry to analyze, separate, identify and synthesize compounds in a biological context.
- Applying this knowledge to solve daily problems.
Topics:
Biomolecules & Biomimetics. Structure, function and biorecognition
Contents: Proteins: enzymes, affinity proteins, antibodies, diabodies, affibodies, avimers, cellular receptors. Biorecognition and function: enzyme/substrate; antigen/antibody; receptor/ligand interaction. Cell signaling. DNA/RNA structure and function. Amplification. Molecular beacons. Aptamers.Molecular imprinted polymers and plastic antibodies.
Metal-containing biomolecules: structure, function, and mimetics.
Content: The biochemistry of metal ions. Uptake, transport and storage of metal ions in biology. Electron transfer, respiration, and photosynthesis. Oxygen metabolism. Other metaloproteins of interest. Metal ion receptors and signaling. Metals in medicine.
Computational techniques in biomolecular chemistry
Content: Specificities of computation at the interface chemistry-biology. Relationship between chemical, biological and conformational space. Protein-ligand dockings. Molecular Dynamics. Multiscale. Advantages, limitations. Reactivity in biochemical systems. Examples.
Molecules for diagnostic imaging
Content: General aspects of imaging techniques. SPECT radiopharmaceuticals based on Tc-99m (nuclear and chemical properties, kit reactions and some examples of relevant technetium radiopharmaceuticals). Other SPECT radiopharmaceuticals. PET radiopharmaceuticals and 18F based radiotracers. Therapeutic and theranostic radiopharmaceuticals.
Natural products: biosynthesis and properties
Content: Natural products in drug discovery and therapeutic medicine: historical overview. Carbohydrates, the sweet molecules of life. The acetate pathway: fatty acids and polyketides. The mevalonate pathway: terpenoids and steroids. The shikimate pathway: aromatic aminoacids and phenyl propanoids. Alkaloids: molecules that changed the world.
Biomolecule production, separation, modificationand determination
Contents: Isolation and production of biomolecules. The immune system: production of polyclonal and monoclonal antibodies. Separation strategies. Labelling with nanotags and immobilization of biomolecules on nanostructured materials. Bioanalysis: immunochemical methods, DNA assays, PCR, biological catalysed methods, other biological catalysts: DNAzymes, biosensing. Chips and arrays.
Nanomaterials in biosciences
Contents: Biorecognition with biologically-modified quantum dots, carbon nanotubes, metal and magnetic nanoparticle: medical diagnosis, nanomedicine and bioanalysis.
Title | Hours | ECTS | Learning Outcomes |
---|---|---|---|
Type: Directed | |||
Lectures | 30 | 1.2 | 6, 7, 12 |
Problems | 8 | 0.32 | 2, 10, 13 |
Type: Supervised | |||
Tutorials | 5 | 0.2 | 5, 10, 11 |
Type: Autonomous | |||
Autonomous learning and studying | 49 | 1.96 | 5, 9 |
Preparation of oral presentation and papers | 40 | 1.6 | 2, 5, 10, 9, 13 |
Lectures
Problem-solving lectures
Cooperative activities
Seminars
Preparation and oral presentation of papers
Tutorials
Annotation: Within the schedule set by the centre or degree programme, 15 minutes of one class will be reserved for students to evaluate their lecturers and their courses or modules through questionnaires.
Title | Weighting | Hours | ECTS | Learning Outcomes |
---|---|---|---|---|
Oral defense of projects | 40 % | 6 | 0.24 | 3, 5, 11, 13 |
Reports and problems | 30 % | 4 | 0.16 | 2, 5, 6, 7, 12 |
Writing assessment | 30 % | 8 | 0.32 | 1, 4, 5, 6, 10, 9, 8, 12 |
The evaluation of this module will take into account the attendance and participation in class as well as the work and assessments presented by the students. All subjects are compulsory attendance. The different topics presented by each of the professors will be separately evaluated, by different assesments including writing exams, theoretical and practical tests, oral presentations, research papers discussion, in-class brief questions, written works, etc.
- Every professor decides the number and typology of evaluation activities: oral presentations, written exams, delivery of discussed articles, tests.
- The final mark of the module will be the sum of the marks of every professor multiplied by the percentage of his classes in the total teaching of the module.
- To pass a module, it is mandatory to have a mark of 3.5 or higher in 75% of all the activities in order to average with other marks of the professor and/or the module.
- There will be a period in January to repeat written exams with marks under 5. In the case of exams under 3,5, it will be mandatory to the student. In the case of exams between 3,5 and 5 it would be optional.
- The marks of other evaluations activities (i. e. oral presentations) will average with the rest of the marks of the professor/module independently of the value. There will be not option of repeating these evaluation activities.
VERY IMPORTANT: Partial or total plagiarising will immediately result in a FAIL (0) for the plagiarised exercise and the WHOLE subject. PLAGIARISING consists of copying text from unacknowledged sources -whether this is part of a sentence or a whole text - with the intention of passing it off as the student's own production. It includes cutting and pasting from internet sources, presented unmodified in the student's own text. Plagiarising is a SERIOUS OFFENCE. Students must respect authors' intellectual property, always identifying the sources they may use; they must also be responsible for the originality and authenticity of their own texts.
In the event of a student committing any irregularity that may lead to a significant variation in the grade awarded to an assessment activity, the student will be given a zero for this activity, regardless of any disciplinary process that may take place. In the event of several irregularities in assessment activities of the same subject, the student will be given a zero as the final grade for this subject.
Medicinal natural products. A biosynthetic approach, P.M. Dewick, Jonh Wiley & Sons, 2002
Química Bioinorgánica, J. S. Casas, V. Moreno, A. Sánchez, J. L. Sánchez, J. Sordo, Editorial Síntesis, Colección Biblioteca de Químicas, 2002
Bioanalytical Chemistry, S. Mikkelsen, E. Corton, Wiley, 2004
Molecular Modelling Principles and Applications - Second Edition -Andrew R. Leach - Ed: Prentice Hall 2001
Addicional Bibliography
Natural Products: their chemistry and biological significance, J. Mann, R.S. Davidson, J. B. Hobbs, D.V. Banthorpe, J. B. Harborne Prentice Hall, 1994
Natural Products Chemistry: A mechanistic and biosynthetic approach to secondary metabolism, K.B.G. Torsell, John Wiley & Sons, 1983
Inorganic Chemistry in Biology,P. C. Wilkins, R. G. Wilkins, Oxford Chemistry Primers, n. 46, Oxford University Press, 1997
Principles of Bioinorganic Chemistry, S. J. Lippard, J.M. Berg, University Science Books, 1994
Principles and Practice of Bioanalysis, R. F.Venn, (Editor), Taylor & Francis, 2000.
Bioanalytical Chemistry, A. Manz, N. Pamme, D. Iossifidis, Imperial College Press, 2004.
Principles of Chemical and Biological Sensors, D. Diamond (Editor), Wiley, 1998.
Biosensors, Elizabeth A.H. Hall, Open Univ Press, 1991
ChemDraw
Name | Group | Language | Semester | Turn |
---|---|---|---|---|
(TEm) Theory (master) | 1 | English | first semester | morning-mixed |