Content

Contents by devices and systems
										
											The subject is structured in two distinct parts, diseases of the digestive system and diseases of the blood. It includes the theoretical content and clinical cases corresponding to each of them. The necessary clinical practices related to these two devices or systems and which complement MiC III, are included in another compulsory subject, Medical-Surgical Practices II.
										
											The contents of the subject are indicative. Each teaching unit will be able to adapt and specify in its programme, the subjects, the teaching staff, the teaching types and the timetable assigned to each one.
										
											
										
											A) DISEASES OF THE DIGESTIVE SYSTEM (4 credits)
										
											Distribution of hours and teaching types
										
											44 hours (Theory 33 hours; Clinical cases 11 hours -seminars 7 hours, simulation 4 hours-)
										
											Medical 19h (theory 13h, seminars 5h, simulation 1h)
										
											Surgical 25h (theory 20h, seminars 2h, simulation 3h)
										
											THEORETICAL CLASSES (33h)
										
											1. Oral and maxillofacial pathology: most relevant diseases of the oral cavity
										
											2. Malignant and benign tumors of the lip, mouth and tongue
										
											3. Gastroesophageal reflux and esophagitis. Esophageal motor disorders. Other esophagitis (eosinophilic esophagitis)
										
											4. Benign and malignant esophageal tumors. Surgical treatment
										
											5. Dyspepsia, gastritis, H. pylori infection and gastroduodenal ulcer
										
											6. Benign esophageal surgical pathology. Surgical complications of peptic ulcer
										
											7. Benign and malignant gastric tumors. Surgical treatment
										
											8. Irritable bowel syndrome. Gastrointestinal motor pathology and constipation
										
											9. Intestinal malabsorption
										
											10. Inflammatory bowel disease
										
											11. Peritonitis. Acute appendicitis.

12. Intestinal occlusion
										
											13. Intestinal ischemia
										
											14. Diverticular disease of the colon
										
											15. Intestinal polyposis. Tumors of small intestine. Colon cancer I
										
											16. Colon and rectal cancer II
										
											17.Benign anorectal pathology
										
											18. Pathology of the abdominal wall.
										
											19. Abdominal injuries
										
											20. Acute hepatitis and fulminant liver failure.
										
											21. Chronic hepatitis: viral and autoimmune
										
											22. Liver diseases due to drugs and toxins. Alcoholic liver disease.
										
											23. Liver cirrhosis. ascites Spontaneous bacterial peritonitis. Hepatorenal syndrome
										
											24. Portal hypertension. Bleeding from varicose veins. Hepatic encephalopathy
										
											25. Non-alcoholic fatty liver and metabolic liver diseases:, Wilson and Haemochromatosis
										
											26. Hyperbilirubinemia, hereditary and acquired cholestasis: primary biliary cirrhosis, sclerosing cholangitis.
										
											27. Benign and malignant liver tumors. Hepatocarcinoma, cholangiocarcinoma
										
											28. Basics of liver surgery
										
											29. Vascular and cystic diseases of the liver. Liver abscess. Liver and pregnancy.
										
											30. Cholelithiasis and acute cholecystitis. Pathology of the main bile duct. Neoplasia of the gallbladder and bile ducts
										
											31. Acute pancreatitis and chronic pancreatitis
										
											32. Pancreatic cancer and other exocrine tumors
										
											33. Digestive transplants

CLINICAL CASES (11am)
										
											Specialized seminars (7 hours)
										
											1. Dysphagia and heartburn - Functional digestive examinations
										
											2. Diarrhea / inflammatory bowel disease - malabsorption.
										
											3. Digestive bleeding
										
											4. Clinical cases of digestive surgical pathology. Proctology
										
											5. Clinical cases. Digestive oncological surgery
										
											6. Acute and chronic hepatitis
										
											7. Hepatic space-occupying lesions
										
											
										
											Simulation (4h)
										
											1. Clinical cases of digestive surgical pathology.
										
											2. Clinical cases of digestive surgical pathology. Sharp abdomen
										
											3. Cirrhotic complications
										
											4. Obstructive jaundice

B) DISEASES OFTHE BLOOD (3 credits)
										
											Distribution of hours and teaching types
										
											33 hours (Theory 26h; Clinical cases 7h -seminars 6h, simulation 1h-)
										
											Medical 30h (theory 24h, seminars 5h, simulation 1h)
										
											Surgical 3h (theory 2h, seminar 1h, simulation 0h)
										
											
										
											THEORETICAL CLASSES (26 hours)
										
											1. Main hematological syndromes. Basic hematological tests
										
											Know and identify the main hematological syndromes (anaemic, neutropenic, hemorrhagic, bone marrow failure, polyglobulic, adenopathic, dysglobulinemic and splenomegalic). Know and interpret the results of the basic analytical tests in hematology (hemogram, basic coagulation tests, erythrocyte indices)
										
											2. Special tests in hematology
										
											Know the main types, basics and indications of the special tests used in Hematology (cyto/histology, immunophenotype, cytogenetics and molecular genetics)
										
											3. Anemia. classification Iron deficiency anemia. Anemia of chronic diseases. Megaloblastic anemias and other macrocytic anemias
										
											Properly classify an anemia. Diagnose the cause and treat iron deficiency anemia. Diagnose anemia associated with chronic diseases. Know the various causes of macrocytic anemia. Diagnose and treat megaloblastic anemia due to vitamin B12 and folic acid deficiency
										
											4. Congenital and acquired hemolytic anemias
										
											Identify a hemolytic syndrome. Make the etiological diagnosis. Know the diagnostic tests and the various treatments used in hemolytic anemias depending on the type. Diagnose and treat paroxysmal nocturnal hemoglobinuria.
										
											5. Quantitative and qualitative alterations of the leukocyte system
										
											Know the main causes of leukopenia, especially neutropenia. Identify and treat agranulocytosis. Know the main causes of leukocytosis. Identify and make the differential diagnosis of a leukoerythroblastic syndrome

6. Bone marrow failure: bone marrow aplasia and myelodysplastic syndromes
										
											Know the causes of global and selective spinal cord insufficiency. Diagnose,know the severity and treat a bone marrow aplasia.
										
											Be clear about the concept and diagnosis of a myelodysplastic syndrome. Know the prognosis and the different treatments used depending on the risk of the disease.
										
											7. Acute leukemias. Acute lymphoblastic leukemia
										
											Classify acute leukemias based on morphological, immunological, cytogenetic and molecular criteria.
										
											Acute lymphoblastic leukemia. Clinic, diagnosis and prognosis. Know the types of treatment and their results.
										
											8. Acute myeloblastic leukemia. Special aspects of the treatment of patients with acute leukemia.
										
											Clinic, diagnosis and prognosis of acute myeloblastic leukemia and its several main subtypes. Know the types of treatment and their results.
										
											Know the special aspects of the treatment of patients with acute leukemia.
										
											9. Chronic myeloproliferative neoplasms (NMPC) without Philadelphia chromosome
										
											Identify the three types of NMPC without the Philadelphia chromosome. Know the diagnostic criteria for each of them and differentiate them from each other and from secondary cases. Know the characteristic molecular alterations and classic and modern treatments.
										
											10. Chronic myeloproliferative neoplasms with Philadelphia chromosome: chronic myeloid leukemia (CML). Other NMPCs
										
											CML clinic, diagnosis, treatment and prognosis. Other diseases related to NMPC
										
											11. Benign and malignant nodal pathology. Surgical aspects.
										
											Know the systematic study of an adenopathic syndrome. Know the surgical aspects of adenopathies. Know the benign processes and those of uncertain malignancy that occur with adenopathies.

12. Malignant lymphomas. Classification and extension study. Hodgkin's lymphoma
										
											Know the basics of the modern classification of lymphomas. Know the anatomopathological, immunological, genetic and molecular characteristics of the most frequent types of lymphomas.
										
											Clinic, diagnosis and treatment of Hodgkin's lymphoma.
										
											13. Aggressive non-Hodgkin's lymphomas
										
											Clinic, diagnosis and treatment of the main types of B-line and T-line lymphomas.
										
											14. Indolent lymphoid neoplasms. Chronic lymphatic leukemia
										
											Know and classify the various types of indolent lymphoid neoplasms, with special emphasis on chronic lymphatic leukemia.
										
											15. Monoclonal gammopathy. multiple myeloma
										
											Clearly distinguish a monoclonal gammopathy of uncertain significance from a malignant monoclonal gammopathy. Know the clinic, diagnosis, prognosis and treatment of multiple myeloma,
										
											16. Other monoclonal gammopathy: Macroglobulinemia of Waldenström. Amyloidosis AL
										
											Know the clinic, diagnosis, prognosis and treatment of Waldenström's macroglobulinemia and AL amyloidosis
										
											17. Diseases of the phagocytic mononuclear system
										
											Classify the main diseases of the phagocytic mononuclear system. Hemophagocytic syndrome. Cumulative histiocytosis (thesaurismosis). Main types of proliferative histiocytosis.
										
											18. Surgical pathology of the spleen
										
											Know hypersplenism and splenic hypofunction. Classification of splenomegaly. Know the tributary diseases of surgery on the spleen. Know the main types and indications of surgical interventions on the spleen: open and laparoscopic splenectomy, conservative surgery. Care of the splenectomized patient.
										
											19. Hemostasis disorders. Angiopathic purpuras, thrombocytopenias and thrombocytopaties
										
											Know the semiology and main tests for the study of hemostasis. Classify the main types of hemostasis disorders. Know the main causes of vasculopathic, thrombocytopenic and thrombocytopathic purpura. Treat the most common causes (eg immune thrombocytopenic purpura).

20. Congenital and acquired coagulopathies
										
											Know the main causes of congenital coagulopathy, as well as the diagnostic tests. Haemophilia and von Willebrand disease, clinical features, severity criteria and treatment. Know the most frequent acquired coagulopathy, their diagnosis and the various treatments available
										
											21. Hypercoagulability.
										
											Know the genesis of arterial and venous thrombosis, the genetic bases and acquired factors of thrombosis.
										
											22. Anticoagulant and thrombolytic treatment
										
											Know the indications, contraindications, risks and complications of the various drugs used in both anticoagulant and thrombolytic treatment. Know the organization of an anticoagulant treatment consultation and a thrombosis study and treatment unit.
										
											23. Hemotherapy
										
											Know the main blood products and the specific indications for the transfusion of each of them, as well as the complications of the transfusion. Know the various apheresis procedures (cytapheresis, plasma exchange). Learn how a blood bank works.
										
											24. Immunotherapy strategies and therapies aimed at Hematology.
										
											Learn the basics and types of targeted therapies and immunotherapeutic strategies in hematology, with special emphasis on monoclonal antibodies and CAR T cell therapy
										
											25. Transplantation of hematopoietic progenitors
										
											Know the indications, procedure, complications, types and results of the transplantation of hematopoietic progenitors.
										
											26. Integrated vision of Hematology and Hemotherapy
										
											Know the integrated operation of a clinical hematology unit (hospitalization and outpatient/day hospital), a multidisciplinary hematology laboratory and a blood bank

Methodology of classes
										
											The teaching methodology will be of two types:
										
											a. Theoretical-practical class taught by the teacher, which will include a summary of the theoretical topic and the discussion of a representative clinical case. Three of the classes will be given in English. A key recent article on the topic of each class will be provided if students want to expand their knowledge.
										
											b. Classes prepared by students. They will be agreed at the beginning of the course, in number of three. They can also be prepared in English, by prioragreement. They can be done in groups. The preparation of classes will be considered a merit towards the final evaluation of the subject
										
											
										
											CLINICAL CASES (7 hours)
										
											Seminars (6h)
										
											1. Resolution of clinical cases: anemias
										
											Group discussion, supervised and structured of guide signs, differential diagnosis, clinical diagnosis, proposed treatment of a clinical case previously prepared at an individual level in the programmed pathology tutorials of the red series.
										
											2. Resolution of clinical cases: pancytopenia
										
											Group discussion, supervised and structured of guide signs, differential diagnosis, clinical diagnosis, proposed treatment of a clinical case previously prepared at an individual level in the programmed pancytopenia tutorials.
										
											3. Resolution of clinical cases: adenopathy
										
											Supervised and structured group discussion of guide signs, differential diagnosis, clinical diagnosis, proposed treatment of a clinical case previously prepared at an individual level in the programmed tutorials corresponding to a lymph node disease
										
											4. Resolution of clinical cases: bleeding disorders
										
											Group discussion, supervised and structured of guide signs, differential diagnosis, clinical diagnosis, proposed treatment of a clinical case previously prepared at an individual level in the scheduled tutorials of a bleeding disorder.
										
											5. Resolution of clinical cases: thrombosis
										
											Group discussion, supervised and structured of guide signs, differential diagnosis, clinical diagnosis, proposed treatment of a clinical case previously prepared at an individual level in the programmed tutorials of a thrombotic disease
										
											6. Resolution of clinical cases: Splenomegaly
										
											Group discussion, supervised and structured of guide signs, differential diagnosis, clinical diagnosis, proposed treatment of a clinical case previously prepared at individual level in the programmed tutorials corresponding to a disease that runs with splenomegaly.
										
											Simulation (1h)
										
											It will be based on the resolution of a clinical case with the presence of a patient (actor)

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