Medical Immunology
Code: 102928 ECTS Credits: 4| Degree | Type | Year | Semester |
|---|---|---|---|
| 2502442 Medicine | OB | 3 | 0 |
Contact
- Name:
- Eva Maria Cabeza Martinez Caceres
- Email:
- evamariacabeza.martinez@uab.cat
Teaching groups languages
You can check it through this link. To consult the language you will need to enter the CODE of the subject. Please note that this information is provisional until 30 November 2023.
Teachers
- Marta Vives Pi
- Oscar de la Calle Martin
- Juan Francisco Delgado de la Poza
- Manuel Hernández González
- Andrés Baucells de la Peña
- Aina Teniente Serra
- Maria Teresa Sanz Martinez
- Laura Martinez Martinez
- Germán Julia Agullo
- Anais Mariscal Rodriguez
- Laura Viñas Giménez
- Marc Boigues Pons
- Joan Climent Martí
- Janire Perurena Prieto
- Federico Fondelli
- Maria Esther Moga Naranjo
- Mónica Martínez Gallo
External teachers
- Bibiana Quirant Sanchez
- Clara Franco Jarava
- Maria Iglesias Escudero
- Romina Dieli Crimi
Prerequisites
It is advisable that the student has attained basic skills in cell biology, biochemistry, genetics and molecular biology before enrolling in the immunology course.
It is absolutely necessary to have acquired sufficient knowledge in: general and specific anatomy and physiology of different organs and systems.
The student will preserve the confidentiality and professional secrecy of the data to which he / she may have access through to the learning process in the health care provider facilities. In addition, he/she behavior will follow the professional ethical code.
Objectives and Contextualisation
1) To know the essentials features of the molecular, cellular, anatomical elements of the immune system (SI) and their function in the healthy individual.
2) To understand the role of the immune system in the following pathological processes:
a. Common infections
b. Allergies and hypersensitivity in general
c. Immune-mediated diseases, autoimmune, autoinflammatoty and other
d. Immunodeficiencies
e. Cancer
F. Transplantation
3) To understand the basic action mechanisms of immune-based therapies:
a) Vaccines,
b) Immunosuppressants,
c) Immunemodulators
4) To learn and understand the basis of the laboratory and clinical tests that have diagnostic value for the immune mediated diseases
Competences
- Demonstrate basic research skills.
- Demonstrate knowledge of the principles and physical, biochemical and biological processes that help to understand the functioning of the organism and its disorders.
- Demonstrate understanding of the basic sciences and the principles underpinning them.
- Demonstrate understanding of the functions and interrelationships of body systems at different levels of organisation, homeostatic and regulatory mechanisms, and how these can vary through interaction with the environment.
- Demonstrate understanding of the manifestations of the illness in the structure and function of the human body.
- Demonstrate understanding of the mechanisms of alterations to the structure and function of the systems of the organism in illness.
- Demonstrate understanding of the organisation and functions of the genome, the mechanisms of transmission and expression of genetic information and the molecular and cellular bases of genetic analysis.
- Demonstrate understanding of the structure and function of the body systems of the normal human organism at different stages in life and in both sexes.
- Demonstrate understanding of the structure and function of the human organism in illness, at different stages in life and in both sexes.
- Establish the diagnosis, prognosis and treatment, basing decisions on the best possible evidence and a multidisciplinary approach focusing on the patient's needs and involving all members of the healthcare team, as well as the family and social environment.
- Formulate hypotheses and compile and critically assess information for problem-solving, using the scientific method.
- Indicate the basic diagnosis techniques and procedures and analyse and interpret the results so as to better pinpoint the nature of the problems.
- Maintain and sharpen one's professional competence, in particular by independently learning new material and techniques and by focusing on quality.
- Organise and plan time and workload in professional activity.
- Put forward suitable preventive measures for each clinical situation.
Learning Outcomes
- Demonstrate basic research skills.
- Describe the main forms of preventive immunotherapy, especially vaccines and the mechanism by which they provide protection.
- Describe the particular genetic mechanisms that generate unique genes in each lymphocyte during development.
- Describe the position and objectives of immunology among the basic health sciences.
- Describe the therapy principles applicable to immunomediated diseases.
- Differentiate the functions of the immune system and how it interacts with other organ systems and reacts to germs by developing immune defence responses.
- Enumerate the main injuries and functional changes that the immune system can cause.
- Explain the biochemical and biological bases of the functioning of the immune system.
- Formulate hypotheses and compile and critically assess information for problem-solving, using the scientific method.
- Identify the indications of immunological tests.
- Identify the main mechanisms by which the immune system can cause or contribute to illness.
- Identify the paradigmatic diseases of the different types of immunomediated diseases.
- Identify the role of should structures and system with organs and and system.
- Interpret in the physiological and pathological context the main techniques for determining the state of the immune system and diagnosing immunomediated diseases.
- Maintain and sharpen one's professional competence, in particular by independently learning new material and techniques and by focusing on quality.
- Organise and plan time and workload in professional activity.
- Understand the role of genetic polymorphisms in the immune response.
Content
Contents of the subject by teaching units
Block 1 Basic Immunology
UD1 Introduction to immunology
UD2 Natural Immunity
UD3 Clonal receptors and their ligands
UD 4 Cells of the immune system
UD5 The immune response, regulation and effectors
Block 2 Immunopathology
UD6 The immune response in the whole organism and disease
UD7 immune responses in special clinical situations
UD8 Diagnostic tests in clinical immunology
UD9 immunology based therapies
Methodology
This guide describes the contents, methodology and general rules of the course, in accordance with the current curriculum.
The Medical Immunology course runs during a semester and contains many new concepts and theferore attending lectures and daily study is strongly encouraged. Periodically on-line questionnaire will be used to assess the progress in the understanding by the students of the concepts presented and discussed in the lectures and seminars. Attending at least six keynote lectures is compulsory.
Immunological concepts will be applied by the student to paradigmatic clinical cases presented in seminars.
Some aspects of the organization of the teaching activities e.g. dates of the practicals and exams, will depend on the particular circumstances and facilities of the different teaching facilities that the university has in each of the UAB affiliated hospitals where the course is imparted.
For the current academic year, the responsible faculty designated by the department are:
Overall coordination Prof: Eva Martínez Cáceres
Hospital coordinators
Vall d'Hebron: Manuel Hernandez
Germans Trias i Pujol: Eva Martínez Cáceres
Sant Pau: Óscar de la Calle Martín
Parc Taulí: Juan Francisco Delgado de la Poza
In the current exceptional circumstances, at the discretion of the teachers and also depending on the resources available and the public health situation, some of the theoretical classes, practicals and seminars organized by the Teaching Units may be taught either in person or virtually.
Annotation: Within the schedule set by the centre or degree programme, 15 minutes of one class will be reserved for students to evaluate their lecturers and their courses or modules through questionnaires.
Activities
| Title | Hours | ECTS | Learning Outcomes |
|---|---|---|---|
| Type: Directed | |||
| CLASSROOM PRACTICES (PAUL) | 2 | 0.08 | 7, 9, 11, 12, 14 |
| CLINICAL CASE SEMINARS (SCC) | 3 | 0.12 | 5, 9, 11, 10, 12, 14 |
| LABORATORY PRACTICALS (PLAB) | 3 | 0.12 | 10, 14 |
| Specialized seminars (SEM) | 2 | 0.08 | 17, 3, 5, 2, 6, 7, 8, 13, 11, 10, 12, 14, 15 |
| THEORY (TE) | 35 | 1.4 | 17, 3, 5, 4, 2, 6, 7, 8, 9, 11, 12, 15 |
| Type: Autonomous | |||
| SELF STUDY.READING ARTICLES/REPORTS OF INTEREST | 49.5 | 1.98 | 17, 3, 5, 4, 2, 6, 7, 8, 9, 11, 10, 12, 15 |
Assessment
Continuous evaluation:
Attendance at practices and seminars is mandatory (equal to or greater than 80%)
a.-Written tests (75% of the grade of the subject):
-A partial exam (comprising the basic teaching units) consisting of a multi-choice questionnaire and a short-question questionnaire. It represents 30% of your final grade. The partial will be liberatory with a minimum score of 6.
- A final exam comprising two parts: a part of the basic units (if they have not been previously released) and a part of the clinical units, including theoretical aspects of the practices and seminars (45% of the final grade).
To pass the subject it will be necessary to reach a minimum final score of the written tests of 5.
b.-Other continuing education activities (25% of the grade of the subject):
Exercises of practices, works and questionnaires; presential or in moodle
To be evaluable the student must pass the practices and seminars (in all cases) with attendance and minimum grade of 5.
c.- Final evaluation:
Students who have not passed the subject through the continuous evaluation of written tests, may be presented to a retrieval exam of the written tests, provided that they have the attendances and evaluations of seminars and practices approved.This exam consists of topics (50%) and short questions(50%) that include all didactic units, seminars and practices and is necessary overcome it with a 5 to pass the subject. It represents 75% of the grade of the subject.
Unique assessment:
For students who select this evaluation option, attendance at practicals and seminars is highly recommended. Students who have at least 80% attendance at practicals and seminars will not have to take a practical exam. In all cases, the mandatory practical or seminar assignments must be submitted on the day of the exam.
a.- The single assessment will consist of a final examination , including theoretical aspects, practices and seminars and resolution of clinical cases.
a.1) Weighting for students who have attended at least 80% of practicals and seminars: test questions (40%) and short questions (60%).
a.2) Weighting for students who have NOT attended at least 80% of practicals and seminars: test questions (25%), short questions (60%). In addition, there will be a practical exam (including practice questions, from the seminars and resolution of clinical cases). The weight of the practical exam will be 15% of the final grade.
The exam will have 100% of the weight of the final grade. In the case of mandatory assignments to pass the subject, they will be delivered/presented (if oral) on the same day of the exam.
b.- Final evaluation:
Students who have not passed the subject through the single assessment may take a final exam. This consists of topics (50%) and short questions (50%) that include all teaching units, seminars and practicals. The student must obtain minimum a 5 to pass the subject. It represents 100% of the subject grade. In the case of mandatory assignments, they will be delivered/presented (if oral) on the same day as the exam.
Assessment Activities
| Title | Weighting | Hours | ECTS | Learning Outcomes |
|---|---|---|---|---|
| Attendance and active participation in classes and seminars evaluated with face-to-face and/or online questionnaires | 10% | 0.5 | 0.02 | 17, 3, 5, 4, 2, 6, 7, 8, 9, 13, 11, 12, 15, 16 |
| Evaluation through case studies, reports and problem solving seminars, evaluated with face-to-face and / or online questionnaires | 15% | 2.5 | 0.1 | 1, 5, 2, 9, 10 |
| Written evaluation objective tests | 75% | 2.5 | 0.1 | 17, 1, 3, 5, 4, 2, 6, 7, 8, 9, 13, 11, 10, 12, 14, 15, 16 |
Bibliography
Main Textbooks
Kuby - Immunology. 8a edició Ed. WH Freeman 2018
Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai. Cellular and Molecular Immunology: 9à edició. Elsevier Saunders, 2017. Amb access on line per estudiants; ISBN-13: 978-0323479783
Janeway's Immunobiology. 9th ed. Kenneth Murphy and Casey Weaver (Author)Garland Science, 2017, ISBN-13: 978-0815345053
Other recommended textbooks
Roitt's Essential Immunology, Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt Wiley-Bolcall, 2016. ISBN-13: 978-1118415771
Kuby - Immunology. 7a edició en espanyol.
Peter Parham; The Immune System, Garldand Science, 4rd edition, 2014.
Addtional reading
Clinical Immunology, Principles and Practice. Robert R Rich. 4ª edició Mosby, 2019. ISBN-13: 978-0723436911
Federation of Clinical Immunology Societies (FOCIS) (www.focisnet.org).
Internet resources
http://www.roitt.com, Figures, and questionnaires for self assessment
Videos on line
Els increibles videos de microscopia multifotónica de Ronal N Germain
https://www.niaid.nih.gov/research/ronald-n-germain-md-phd
Software
power point