Degree | Type | Year | Semester |
---|---|---|---|
4313794 Biochemistry, Molecular Biology and Biomedicine | OB | 0 | A |
Graduates in Biochemistry, Biotechnology, Biology, Biomedical Sciences, Genetics, Microbiology, Medicine, Chemistry, Pharmacy, Computing Sciences, Physics, or Veterinary Medicine.
English is the only language used in the course. That includes class explanations by the instructors, tutorials, discussions in the classroom, materials, oral presentations by the students, and evaluated assignments. Therefore, an upper-intermediate level (B2, Cambridge First, TOEFL 87-109) is highly recommended.
The global objective of the course is for the student to acquire fundamental competencies in Biochemistry, Molecular Biology, and Biomedical research, to gain a solid grounding as a biomolecular scientist. Specific objectives are detailed in the Content section.
1- At the bench
1.1- Experimental Design
Instructor
David G. Quintana
Objectives
For the student to understand experimental design and data analysis processes.
Contents
- A brief introduction to the epistemology of Science.
- The problem/question framework: Defining the research objective and the best-suited question to address it. What would be an acceptable answer? Defining the experimental project.
- Hypothesis-driven research. Inductive vs deductive reasoning. The need for a testable, falsifiable hypothesis. The new paradigm: Question-driven research. Data-driven research.
- Experimental design. Choosing the optimal experimental system and sample. Instrument calibration and controls. Types of experiments. Variables. Controls. Time courses. Reproducibility.
- Data analysis and interpretation. Analysis of statistical significance. and confidence. Correlation vs causation. Sources of bias. Model formulation; validating the model through predictions that can be tested experimentally.
1.2- Clinical Research
Instructor
Irene Roman
Objectives
For the student to understand the specifics of the different clinical research approaches.
Contents
- Observational studies. Descriptive, ecological, case report/case series. Descriptive and analytic, cross-sectional, case-control, cohort. Mixed.
- Experimental studies, randomized clinical trials.
- Integration of individual studies. Systematic review. Meta-analyses.
- Screening tests. Screening criteria. Reliability. Validity.
- Causality, interaction, confusion.
1.3- Lab Life Basics
Instructors
Oscar Zaragoza, Jaume Farres, Antonio Casamayor, David G. Quintana.
Objective
An overview of general Biolab organization and procedures.
Blocks
- Organization of Biolabs.
- Handling of typical equipment and instruments.
- Your bench.
- Types of storage.
- The lab notebook.
- Lab safety. Good laboratory practices. Disposal of lab waste. How to react when facing spills and other accidents. Working with radioisotopes. Biosafety.
1.4- Scientific Integrity
Instructor
Oscar Zaragoza
Objective
For the student to become aware of the conflicts, tensions and uncertainties encountered in scientific research.
Contents
Case-based learning. Sources of pressure. Misconduct, fabrication, falsification, suppression, plagiarism. Misinterpretation, a priori convictions, insufficient reproducibility. Criteria for authorship.
2- Communication skills in Science
Instructors
Enrique Claro, Antonio Casamayor, Joaquin Arino.
Objectives
- For the student to acquire fundamental skills in written and oral communication of research results, in a concise, clear, honest manner.
- For the student to develop the ability to integrate knowledge and formulate reasonable conclusions from available information.
Blocks
- Oral skills.
- The research article.
- The MSc and PhD thesis.
- Posters.
3- Journal Clubbing
Instructors
Jose R. Bayascas, Ester Boix, Assumpcio Bosch, Miguel Chillon, Elena Galea, Irantzu Pallares, David Reverter, Carles Saura, Natalia Sanchez de Groot, David G. Quintana.
Objectives
An initiation to journal club as an essential, standard tool
- to develop the ability to analyze, reason, and discuss (defend and criticize) scientific results.
- to get acquainted with and understand advanced research work.
- to keep up with constant, fast progress in biomolecular sciences.
- to integrate MSc/PhD students' knowledge in Biochemistry, Molecular Biology, and Biomedicine.
- to practice preparing and delivering oral presentation and discussion/defense of experimental results.
- to serve as a way of identifying some of the current frontiers in biomolecular research, including emerging methods and techniques.
Blocks
- How to critically dissect a research article.
- Relevant articles will be proposed by the different tutors for the students to work on at home, and then present and discuss them in small groups.
4- Computer lab practices
Instructors
Marc Torrent, Martí Aldea.
Blocks
- Data representation and analysis, hypothesis testing.
- Systems biology, simulation, and design of biological systems (COPASI, Complex Pathway Simulator).
This is an eminently practical course, as it is aimed at the acquisition of research competencies and self-confidence by the future biomolecular researcher. In consequence, all sessions are based on practical, experiential learning, where the student is the centre of her/his learning process. For the same reason, the load of (evaluated) work is significant.
In general, TE and SEM sessions will be developed as described below, although the instructor’s specific needs will prevail at all times.
Presentation and discussion of Journal Clubs. The student must prepare the presentation and defence of 5 research articles of his/her choice among the 8 on offer.
Annotation: Within the schedule set by the centre or degree programme, 15 minutes of one class will be reserved for students to evaluate their lecturers and their courses or modules through questionnaires.
Title | Hours | ECTS | Learning Outcomes |
---|---|---|---|
Type: Directed | |||
Full group classes (TE, double helix), split group seminars (SEM, Crick / Franklin), and computer lab practices (PLAB-I) | 17 | 0.68 | 17, 3, 4, 8, 10, 16, 11, 14, 15, 20, 7, 9, 21, 26, 24, 23, 22, 25, 6 |
Type: Supervised | |||
Presentation of assignments and Journal clubs | 10 | 0.4 | 17, 2, 3, 5, 4, 8, 19, 10, 16, 11, 12, 14, 13, 15, 20, 7, 9, 1, 18, 21, 26, 24, 23, 22, 25, 6 |
Supervised work in the classroom | 50 | 2 | 17, 3, 5, 4, 8, 10, 16, 11, 12, 14, 15, 20, 7, 9, 21, 26, 24, 23, 25, 6 |
Tutorials | 5 | 0.2 | 17, 3, 8, 10, 16, 11, 14, 15, 20, 7, 9, 21, 24, 25, 6 |
Type: Autonomous | |||
Work on assignments and on Journal Club | 125 | 5 | 17, 2, 3, 5, 4, 8, 19, 10, 16, 11, 12, 14, 13, 15, 20, 7, 9, 1, 18, 21, 26, 24, 23, 22, 25, 6 |
Continuous evaluation:
Specific details of the different assignments will be provided by the different instructors. The contribution of each block to the final grade is proportional to the workload.
- Experimental design (DGQ 23%)
- Clinical research (IR 8%)
- Scientific communication (EC 22%, JA 9%)
- Scientific integrity, safety, and good practices, biosafety (OZ 7%, JF 4%, AC 2%)
- Computer laboratory practices (MT 5%, MA 5%)
- Presentation and discussion of the Journal Clubs (15%)
Class attendance:
Instructors in Module 1 consider that hands-on, experiential learning is the most powerful learning strategy. For such reason, all face-to-face sessions involve in-class work, which cannot be recovered. Consequently, absences without a documented force majeure reason will average zero proportionally to the missed number of hours.
Late submission of coursework:
Written coursework delivered after the deadline without a documented force majeure reason, will be penalized with a deduction of 10% of the total grade per day of delay, with a limit of 5 days. After the 5 day-limit, a grade of zero will be awarded. This rule will cease to be applicable and the assignment will receive a zero whenever the instructor publishes the solutions to the assignment
Referral evaluation:
Since the evaluation of the module is based on continuous work, much of it in the classroom, there is no referral evaluation option.
Non-assessable:
A student who hands in pieces of evidence that account for less than 2/3 of the total mark will be qualified as "Non-assessable".
Misconduct:
Written works and presentation documents will be scanned with plagiarism detection software. Detection of a single plagiarism event will lead to failing the module with no option for referral evaluation.
Title | Weighting | Hours | ECTS | Learning Outcomes |
---|---|---|---|---|
Presentation and defence of assignments | 85% | 8 | 0.32 | 17, 2, 3, 5, 4, 8, 19, 10, 16, 11, 12, 14, 13, 15, 20, 7, 9, 1, 18, 21, 26, 24, 23, 22, 25, 6 |
Presentation and discussion of Journal Clubs | 15% | 10 | 0.4 | 17, 3, 5, 4, 10, 11, 12, 13, 15, 20, 7, 9, 1, 18, 21, 26, 22, 25, 6 |
The recommended textbooks are available at the UAB libraries.
- At the Bench. A laboratory Navigator. Kathy Barker. Cold Spring Harbor Laboratory Press, 2005.
- Experimental Design for Biologists. David J. Glass. Cold Spring Harbor Laboratory Press, 2007.
- Statistics at the Bench. A Step-by-Step Handbook for Biologists. Martina Bremer. Cold Spring Harbor Laboratory Press, 2009.
- How to Present at Meetings. George M. Hall, Neville Robinson. BMJ Books, London, 2011.
- University of Manchester Academic Phrasebank http://www.phrasebank.manchester.ac.uk/
Software will be provided by the Computer Lab Practices instructors.