Degree | Type | Year | Semester |
---|---|---|---|
2502442 Medicine | FB | 1 | 2 |
Although there are no official prerequisites, it is highly recommended to have passed the subject "Structural Biochemistry and Molecular Biology."
In any case, it is worthy to review the following high school subjects:
The Metabolic Biochemistry subject focuses on the knowledge of the sources, forms of storage and use of energy and nutrients in the human organism, distinguishing the different metabolic specializations.
The main catabolic and anabolic pathways and their regulation are studied. Emphasis is placed on the interrelations of the metabolism of carbohydrates, lipids, amino acids and nucleotides, in the mechanisms of hormonal regulation during the fast-feed cycle; the biochemical alterations present in common metabolic pathologies are also discussed.
The student is expected to achieve a global understanding of human metabolism that will integrate their principal mechanisms, functions and regulation. This understanding will serve, with the help of textbooks, as the basis for further specific topics during the rest of the degree studies, particularly in subjects such as Physiology, Pharmacology or Clinical Biochemistry.
THEMATIC BLOCKS OF THEORY AND SEMINARS:
Unit 1. Introduction to metabolism and its regulation. Biochemistry of cell signalling
Basic concepts of Bioenergetics. Control of energy metabolism. Main routes of inter and intracellular signalling controlling energetic metabolism (5 hours of lectures and 2 hours of specialized seminars).
Unit 2. Common phase of oxidative metabolism
Mitochondrial energy metabolism: pyruvate deshidrogenase, cycle of tricarboxylic acids and oxidative phosphorylation. Oxygen free radicals (4 hours of lectures and 4 hours of specialized seminars).
Unit 3. Structure and metabolism of carbohydrates
Structure, characteristics, origin and function of carbohydrates. Digestion and absorption of carbohydrates. Glycolysis Gluconeogenesis. Glycogen metabolism. Route of the pentoses phosphate. Common alterations in the regulation of carbohydrate metabolism (6 hours of lectures and 4 hours of specialized seminars).
Unit 4. Structure and metabolism of lipids
Structure and characteristics of lipids. Obtaining energy from fatty acids. Synthesis of fatty acids and triacylglycerides. Metabolism of lipids with structural function. Cholesterol metabolism. Transport of lipids in blood by lipoproteins. Common alterations in the regulation of lipid metabolism. (6 hours of lectures and 4 hours of specialized seminars). At the end of the subject, there will be 1 session of a classroom practice about dyslipidemia (2 hours)
Unit 5. Metabolism of nitrogenized compounds
Metabolism of amino acids. Cycle of urea. Metabolism of amino acid derivatives: non-nucleotide and nucleotide nitrogen derivatives (4 hours of lectures and 2 hours of specialized seminars).
Unit 6. Integration and control of metabolism
Metabolic particularities of some tissues.Interrelations between the tissues during the feeding-fast cycle and under particular physiological and pathological states (2 hours of lectures and 4 hours of specialized seminars).
LABORATORY PRACTICES:
The teaching methodology will consist of theory classes (TE), specialized seminars (SEM) where practical and clinical cases will be discussed, laboratory practices (PLAB) and a classroom practice (PAUL), all of them supervised. The main teaching material for these activities will be provided through the UAB Moodle platform.
The theory classes (27 hours) will be given in the form of one hour lectures in which the teachers will also comment on the material available for other activities, including materials for self-learning.
Students will attend specialized seminars in small groups. They will work in small groups for the discussion of course materials, clinical case studies or problem solving (10 sessions of 2 hours). A tutor will act as moderator.
For the laboratory practices (3 sessions of 4 hours) a laboratory handbook will be followed. Students will find a questionnaire to be solved.
The classroom practice on dyslipidemia (1 session of 2 hours) will be given by the Head of the Clinical Biochemistry Service of the Hospital de la Santa Cruz and Sant Pau.
Finally, following the self-study of the students and previously asking for an appointment with the professors, the students will be able to have specific tutorials.
Title | Hours | ECTS | Learning Outcomes |
---|---|---|---|
Type: Directed | |||
CLASSROOM PRACTICES (PAUL) | 2 | 0.08 | 6, 4, 5, 8, 7, 10, 12, 11, 19, 18, 17, 16 |
LABORATORY PRACTICES (PLAB) | 12 | 0.48 | 2, 4, 7, 9, 13, 12, 11, 15, 19, 18, 16, 20 |
SEMINARS (SEM) | 20 | 0.8 | 1, 2, 3, 6, 4, 5, 8, 7, 9, 13, 10, 12, 11, 14, 15, 19, 18, 17, 16, 21, 20 |
THEORY (TE) | 27 | 1.08 | 2, 3, 6, 4, 5, 8, 7, 9, 13, 10, 12, 11, 14, 19, 18, 17, 16, 20 |
Type: Supervised | |||
ACTIVITIES AVAILABLE AT THE MOODLE PLATFORM, PREPARATION OF SEM ACTIVITIES, TUTORIALS | 17.5 | 0.7 | 1, 2, 3, 6, 4, 5, 8, 7, 9, 13, 10, 12, 11, 14, 15, 19, 18, 17, 16, 21, 20 |
Type: Autonomous | |||
SELF STUDY / PREPARATION OF WRITTEN WORKS | 88 | 3.52 | 3, 6, 4, 5, 8, 7, 9, 13, 10, 12, 11, 14, 15, 19, 18, 17, 16, 21, 20 |
The average mark of the subject is calculated based on the grades obtained in 6 assessment activities:
FORMAT OF EXAMS
In all cases, the examinations will be assessments written through objective tests of two types of assessment - multiple choice items and essay tests - aimed at reflecting the achievement of competences and the recognition of concepts.
REQUIREMENTS TO PASS THE SUBJECT
To pass the subject, the final exam mark must be equal or superior at 4,5 and the final mark (result of all the evaluation activities or the recuperaction examen) must be equal to or higher than 5 out of 10.
TEST OF RECOVERY
A few days after the revision of the final exam, a global recovery test will be carried out, in the same format as the final exam, which will aim to re-evaluate the students that have failed the subject. The mark of this exam will be the final grade. It is understood that the students who, having passed the subject by course, decide to present themselves to this test, renounce the mark obtained by course and will obtain the grade of this proof of recovery as grade of the subject.
Students who do not take an evaluation test or who have not passed through the continuous assessment and the final exam, and do not submit to the recovery exam, will be considered Not-assessable.
Title | Weighting | Hours | ECTS | Learning Outcomes |
---|---|---|---|---|
1st short examination of continuous evaluation: Written assessments through objective tests: selection items / essay tests | 15 % of the final mark | 0.5 | 0.02 | 1, 2, 3, 6, 4, 5, 8, 7, 9, 13, 10, 12, 11, 14, 15, 19, 18, 17, 16, 21, 20 |
2nd short examination of continuous evaluation: Written assessments through objective tests: selection items / essay tests | 11% of the final mark | 0.5 | 0.02 | 1, 2, 3, 6, 4, 5, 8, 7, 9, 13, 10, 12, 11, 14, 15, 19, 18, 17, 16, 21, 20 |
3rd short examination of continuous evaluation: Written assessments through objective tests: selection items / essay tests | 11 % of the final mark | 0.5 | 0.02 | 1, 2, 3, 6, 4, 5, 8, 7, 9, 13, 10, 12, 11, 14, 15, 19, 18, 17, 16, 21, 20 |
4th short examination of continuous evaluation: Written assessments through objective tests: selection items / essay tests | 8 % of the final mark | 0.5 | 0.02 | 1, 2, 3, 6, 4, 5, 8, 7, 9, 13, 10, 12, 11, 14, 15, 19, 18, 17, 16, 21, 20 |
Final exam : written avaluations by objective tests: ítems of selection/ assay test | 50 % of the final mark | 6 | 0.24 | 1, 2, 3, 6, 4, 5, 8, 7, 9, 13, 10, 12, 11, 14, 15, 19, 18, 17, 16, 21, 20 |
Laboratory and classroom practices attendance | 5% of the final mark | 0.5 | 0.02 | 2, 3, 7, 9, 11, 15, 19, 18 |
We suggest you the following books. Underlayed the free e-books at the UAB libraries web sites:
Basic books:
Medium complexity books:
Complete books:
Digital resources coreesponding to particular contents of the subject will be published at the Moodle platform through the semester.