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2020/2021

Genetics

Code: 101913 ECTS Credits: 6
Degree Type Year Semester
2501230 Biomedical Sciences FB 1 1
The proposed teaching and assessment methodology that appear in the guide may be subject to changes as a result of the restrictions to face-to-face class attendance imposed by the health authorities.

Contact

Name:
Massimo Bogliolo
Email:
Massimo.Bogliolo@uab.cat

Use of Languages

Principal working language:
catalan (cat)
Some groups entirely in English:
No
Some groups entirely in Catalan:
No
Some groups entirely in Spanish:
No

Teachers

Amadeu Creus Capdevila
Massimo Bogliolo

Prerequisites

Being a course in the first semester of the first course of the degree, it will not be necessary to have previously  knowledge or skills given by any of the courses of the degree.

 

However, the course cannot "start from scratch" since the learning of  Genetics is part of the studies in secondary school. Basic knowledge of Genetics will ease the achievement of the competences of the course.

 

 

 

Objectives and Contextualisation

The science of Genetics studies all related to the hereditary material and inheritance of living beings. It is a basic and fundamental subject in biomedical sciences. The student will acquire a vision from the molecular point of view to population and evolutionary levels of organization. The main goals of this subject are: the comprehension of the basis and mechanisms of the inheritance; the genetic analysis of experimental data and the interpretation of the results; as well as, to achieve a global vision of Genetics.

Competences

  • Act with ethical responsibility and respect for fundamental rights and duties, diversity and democratic values.
  • Describe biomedical problems in terms of causes, mechanisms and treatments.
  • Display knowledge of the basic life processes on several levels of organisation: molecular, cellular, tissues, organs, individual and populations.
  • Display knowledge of the concepts and language of biomedical sciences in order to follow biomedical literature correctly.
  • Make changes to methods and processes in the area of knowledge in order to provide innovative responses to society's needs and demands.
  • Students must be capable of applying their knowledge to their work or vocation in a professional way and they should have building arguments and problem resolution skills within their area of study.
  • Students must be capable of collecting and interpreting relevant data (usually within their area of study) in order to make statements that reflect social, scientific or ethical relevant issues.
  • Students must be capable of communicating information, ideas, problems and solutions to both specialised and non-specialised audiences.
  • Students must develop the necessary learning skills to undertake further training with a high degree of autonomy.
  • Students must have and understand knowledge of an area of study built on the basis of general secondary education, and while it relies on some advanced textbooks it also includes some aspects coming from the forefront of its field of study.
  • Take account of social, economic and environmental impacts when operating within one's own area of knowledge.
  • Work as part of a group with members of other professions, understanding their viewpoint and establishing a constructive collaboration.

Learning Outcomes

  1. Act with ethical responsibility and respect for fundamental rights and duties, diversity and democratic values.
  2. Describe the laws of heredity and the transmission mechanisms of hereditary characteristics.
  3. Describe the processes of replication, expression and regulation of the genome.
  4. Explain the genetic basis for biological variability and evolution.
  5. Make changes to methods and processes in the area of knowledge in order to provide innovative responses to society's needs and demands.
  6. Students must be capable of applying their knowledge to their work or vocation in a professional way and they should have building arguments and problem resolution skills within their area of study.
  7. Students must be capable of collecting and interpreting relevant data (usually within their area of study) in order to make statements that reflect social, scientific or ethical relevant issues.
  8. Students must be capable of communicating information, ideas, problems and solutions to both specialised and non-specialised audiences.
  9. Students must develop the necessary learning skills to undertake further training with a high degree of autonomy.
  10. Students must have and understand knowledge of an area of study built on the basis of general secondary education, and while it relies on some advanced textbooks it also includes some aspects coming from the forefront of its field of study.
  11. Take account of social, economic and environmental impacts when operating within one's own area of knowledge.
  12. Understand the functional and organisational structure of hereditary material.
  13. Use the bibliographic sources specific to cell biology, cytology and histology and genetics to work independently on acquiring further knowledge.
  14. Work as part of a group with members of other professions, understanding their viewpoint and establishing a constructive collaboration.

Content

1.- Introduction to genetics.

2.- Classical genetics analisis. The chromosomal basis of inheritance.

3.- Independent assortment. Extensions of Mendelian genetics.

4.- Non-Mendelian inheritance. 

5.- Human pedigree analysis and genetic counseling.

6.- Quantitative genetics

7.- Mapping eukaryote chromosomes by recombination

8.- Genetic population and evolution

9.- Genetic material 

10.- Gene expression

11.- Regulation of transcription

12.- Mutation and repair

Unless the requirements enforced by the health authorities demand a prioritization or reduction of these contents.

Methodology

The contents of the subject of Genetics are aimed at providing students with a general introduction to the basic concepts of Genetics in order to understand the laws of heredity, its cytological and molecular basis and its variation at the cellular and population levels. These contents include: mendelism; type of heredity; interaction genes and environment; sex determination; ligation and recombination; genetic maps; cytogenetics; structure, organization and metabolism of genetic material; gene regulation; genomics and transcriptomics; mutation and repair of DNA; population and quantitative genetics; evolution.

Theory classes: The student acquires scientific knowledge of the subject by attending theoretical classes, which will be complemented by personal study of the topics covered.

Classes of problems: The knowledge acquired during the theory classes and during the personal study will be applied to solve practical cases. During these problem classes, students will expose problems, acquiring the ability to synthesize, interpret data, and communicate orally.

 

The proposed teaching methodology may experience some modifications depending on the restrictions to face-to-face activities enforced by health authorities.

 

Translated with www.DeepL.com/Translator

Activities

Title Hours ECTS Learning Outcomes
Type: Directed      
Masterclass 36 1.44 12, 3, 2, 4
Problems 8 0.32 13
Type: Supervised      
Tutorials 4 0.16 13
Type: Autonomous      
Autostudy 70 2.8 12, 3, 2, 4, 13
Problem solving 15 0.6 13
Reading and bibliographic search 8 0.32 13

Assessment

In order to evaluate the progressive comprehension and acquisition of the contents, both theory and problems, 2 partial evaluation tests will be carried out that will eliminate matter. The grade of each partial will correspond to 47.5% of the final grade. In order to pass the partial tests and be able to average the student must obtain a minimum grade of 5 in each of the tests.

If the student does not reach 5 in a partial, he will not be able to make average with the score of the other partial and he will have to evaluate the corresponding subject in the make-up exam.

In any situation the course is passed with a final grade of at least 5.

In order to participate in the make-up exam, the student must have been previously evaluated in a set of activities the weight of which is equivalent to a minimum of two thirds of the total grade of the subject or module. Therefore, the student body will obtain the grade of "Not Avaluable" when the evaluation activities carried out have a weighting of less than 67% in the final grade.

Students who cannot attend an assessment test for a justified reason and provide the corresponding documentation will have the right to take the test at another time in agreement with the teacher.

Repeating students must take all the tests required to pass the subject.

Students who have passed the two mid-term exams and wish to raise their marks may take the make-up examinations, this being the final mark that will appear in their file.

A 5% of the final grade will correspond to attendance and participation during classes.

 

Student’s assessment may experience some modifications depending on the restrictions to face-to-face activities enforced by health authorities.

 

Translated with www.DeepL.com/Translator

Assessment Activities

Title Weighting Hours ECTS Learning Outcomes
Class attendance and participation 5% 2 0.08 1, 11, 5, 8, 7, 14
First partial examination 47.5% 3.5 0.14 12, 3, 2, 4, 10, 9, 6, 13
Second partial examination 47.5% 3.5 0.14 12, 3, 2, 4, 10, 9, 6, 13

Bibliography

1. Griffiths, A.J.F., Wessler, S.R., Lewontin, R.C., Carroll, S.B. "Introduction to Genetic Analysis". W.H. Freeman and Co. McGraw-Hill /Interamericana de España, 2008, 8th edition.

2. Pierce, Benjamin A. "Genética un enfoque conceptual", Editorial MédicaPanamericana, 2015, 5th edition.

3. Pierce, Benjamin A. "Fundamentos de genética", Editorial MédicaPanamericana, 2011.

Klug, W.S., Cummings M.R., Spencer C.A., Palladino M.A. "Concepts of genetics". Pearson, 2013, 10th edition.

5. Benito C., Espino FJ. "Genetics: Essential Concepts". Panamericana, 2012.

6. Benito C. "141 Problemas de genética: resueltos paso a paso". Synthesis, 2015.

7. JL cantilever. "Genetics: Problems and exercises solved". Pearson Educación, 2003.

Web:

http://www.ncbi.nlm.nih.gov/books/?term=genetics

Aula Virtual de l'Autònoma Interactiva: https://cv2008.uab.cat

Spanish Society of Genetics: http://www.segenetica.es/

http://bioinf3.uab.cat/genmoodle

Translated with www.DeepL.com/Translator