Degree | Type | Year | Semester |
---|---|---|---|
2500252 Biochemistry | FB | 1 | 2 |
The general objective of the subject is to introduce the student, for the first time, to the theoretical study
of the chemical and biochemical phenomena, that is to say, to the contributions of Physical Chemistry to a life science like Biochemistry.
In the long run, the student has to become aware of the importance of Physical Chemistry as the theoretical basis of Biochemistry, and become familiar with its theoretical and experimental methodology.
The most general objective of the program is to help the student to understand the chemical and biochemical phenomena
of the macroscopic world. The basic concepts of Thermodynamics and Chemical Kinetics will be studied.
At the same time, we also want the student to be aware of the dual-theoretical-experimental character of the
Physical Chemistry. Another general objective is to give the student an interdisciplinary view of Biochemistry, in
particular, its close relationship with Chemistry, Physics, and Mathematics.
Specific objectives:
1) Understand the laws of Classical Thermodynamics and be able to apply them to the study of chemical and biological systems.
2) Know the basic foundations of the Chemical Kinetics and be able to apply them in the study of chemical and biochemical reactions.
3) Distinguish between phenomena governed by Thermodynamics and phenomena governed by Kinetics.
Block 1: Chemical Kinetics
Unit 1: Foundations of Chemical Kinetics. Reaction rate. Rate equation. Order of reaction.
Elemental and complex reactions. Experimental methods. Determination of the reaction order and the rate constant. Integration of the rate equation. Half-life. Differential method of Van't Hoff. Effect
of the temperature on the rate constant. Arrhenius Equation. Activation energy.
Unit 2: Mechanisms of reaction. Mechanisms of first order: reversible, consecutive and
competitive reactions. Approximations of the steady state and equilibrium. General mechanism of chemical catalysis.
Enzyme catalysis. Equation of Michaelis-Menten.
Block 2: Fundamentals of Thermodynamics
Unit 1: Energy. Thermodynamic systems. Laws of Thermodynamics.
Unit 2: Energy transfer: heat and work. Internal energy and enthalpy. Heat capacity at
constant volume and constant pressure. Reversible and irreversible processes. Examples: ideal gas,
chemical and biochemical reactions (Thermochemistry).
Unit 3: Distribution of energy and spontaneity of processes. Entropy. Microscopic interpretation. Criteria of spontaneous change and equilibrium in a system of fixed composition. Gibbs Energy. Application to reactions.
Block 3: Phase equilibrium and chemical equilibrium
Unit 1: Phase transitions. Phase equilibrium condition. Equations of Clapeyron and
Clausius-Clapeyron. Phase diagrams. Gibbs phase rule.
Unit 2: Dissolutions. Partial molar quantities. Specific case: chemical potential. Thermodynamics of mixtures.
Binary mixtures of volatile liquids. Law of Raoult. Henry's Law. Colligative properties.
Unit 3: Chemical equilibrium. Termodynamics equilibrium constant. The response of equilibria to the conditions. Examples of chemical equilibria.
*Unless the requirements enforced by the health authorities demand a prioritization or reduction of these contents.
Students will learn by working. They will have to learn to find knowledge and build them, to work on
team, face and solve problems and find strategies for action.
Theory lectures: they will be carried out by performing developments on the board. It will be treated
to encourage the participation of students during classes. Some practical cases will be solved
to exemplify the theory.
Problem sessions: they are essential for the correct understanding of the subject and for the application of the
concepts studied to the resolution of real problems. The student will have a collection of problems that
will be resolved throughout the course. When the teacher determines it, the delivery of problems will be mandatory.
*The proposed teaching methodology may experience some modifications depending on the restrictions to face-to-face activities enforced by health authorities.
Title | Hours | ECTS | Learning Outcomes |
---|---|---|---|
Type: Directed | |||
Problem sessions | 15 | 0.6 | 1, 4, 6 |
Theory lectures | 30 | 1.2 | 1, 5, 4, 6 |
Type: Supervised | |||
Team work | 10 | 0.4 | 1, 3, 7, 6 |
Type: Autonomous | |||
Study and problem solving | 87 | 3.48 | 1, 5, 4, 7, 6 |
In this subject a continuous evaluation will be carried out. The final grade will be obtained using the following
concepts:
- Work to deliver, 20% (not recoverable).
- Partial exams, 80% (2 in total, 30% the first one and 50% the second one).
To pass the subject per course as a result of the continuous evaluation, the weighted average of the two partial exams and the works to be delivered will be made.
The mark obtained must be at least 5.0. In addition, the two partial exam grades must be at least 4.0 each, and it is mandatory to have a qualification in each work to be delivered.
Final exam: Those students who have not passed the subject per course as a result of
the continous evaluation must go to a final exam, which will cover all the subject. The grade of the final exam will replace the joint note of the two partial exams (80%) and
the mark of the works (20%) will be kept.
To participate in the final exam, the students must have been previously evaluated in a set of activities
the weight of which equals to a minimum of two thirds of the total grade of
the subject. The students will obtain the qualification of "Not Evaluable" if the number of their evaluation activities is less than 67% of the programmed ones for the subject.
*Student’s assessment may experience some modifications depending on the restrictions to face-to-face activities enforced by health authorities.
Title | Weighting | Hours | ECTS | Learning Outcomes |
---|---|---|---|---|
Group evaluation | 20% | 3 | 0.12 | 1, 3, 5, 4, 7, 6, 2, 8 |
Parcial exam 1 | 30% | 2 | 0.08 | 1, 5, 4 |
Partial exam 2 | 50% | 3 | 0.12 | 1, 5, 4, 6 |
1) I. N. Levine, Physical Chemistry, 6th Edition, McGraw Hill, 2009. (Translated edition: Principios de
fisicoquímica, 6ª edició, McGraw Hill, 2014).
2) P.W. Atkins, J. de Paula, Physical Chemistry for the Life Sciences, Oxford University Press, 2006.
3) R. Chang, Fisicoquímica para las ciencias químicas y biológicas, McGraw-Hill, 2008, 3a ed.
4) S.R. Logan, Fundamentos de Cinética Química, Addison Wesley iberoamericana, 2000.
5) R. Chang, Physical Chemistry for the Biosciences, University Science books, 2005.