Microbian Biotechnology
Code: 42900 ECTS Credits: 9| Degree | Type | Year | Semester |
|---|---|---|---|
| 4313772 Advanced Biotechnology | OB | 0 | 1 |
Contact
- Name:
- Neus Ferrer Miralles
- Email:
- Neus.Ferrer@uab.cat
Use of Languages
- Principal working language:
- spanish (spa)
Other comments on languages
The vehicular language is Spanish and some sessions will be given in EnglishTeachers
- Montserrat Llagostera Casas
- Antonio Villaverde Corrales
- Maria Pilar Cortés Garmendia
- Escarlata Rodriguez Carmona
- Esther Vazquez Gomez
- José Luis Corchero Nieto
External teachers
- Antonio Barreiro Vázquez
- Antonio Párraga Tajuelo
- Elena García Fruitós
- Marí Aldea Malo
- Ursula Rinas
Prerequisites
Good knowledge of microbial metabolism and physiology, molecular microbiology and culture techniques, genetic manipulation of microorganisms and engineering of recombinant proteins are required.
Objectives and Contextualisation
The objective of this module is to provide students with an overview of microorganisms of industrial interest, microbial diversity and their potential on an industrial scale in production / transformation processes.
There will also be several microbial products of industrial and biomedical interest, especially proteins, and how microbial cell factories can be used for the production and adaptation of the same for biotechnological and biomedical applications.
Competences
- Combine knowledge of microbial genetics and physiology with the methodologies of bioprocess engineering in Cell Factory applications .
- Communicate and justify conclusions clearly and unambiguously to both specialist and non-specialist audiences.
- Comparatively integrate physiological microbial diversity and the potential application of microbial products and transformations mediated by microorganisms in the biotechnological, pharmaceutical and food industries.
- Handle the biological methodologies and principles that underpin the microbial production of recombinant proteins.
- Solve problems in new or little-known situations within broader (or multidisciplinary) contexts related to the field of study.
- Use and manage bibliography and IT resources related to biotechnology responsibly.
Learning Outcomes
- Apply basic concepts in microbiology to industrial processes based on biotechnology.
- Communicate and justify conclusions clearly and unambiguously to both specialist and non-specialist audiences.
- Determine the best genetic strategies for the production of recombinant proteins.
- Determine the most appropriate type of process for a microbial production strategy.
- Determine which types of microbial products are potentially of interest in biotechnology.
- Integrate molecular and physiological tools and strategies in microbial production and transformations.
- Recognise microbial diversity as a biotechnological offer for the cell factory.
- Show scientific judgement in choosing the appropriate organism to produce high-quality recombinant proteins.
- Solve problems in new or little-known situations within broader (or multidisciplinary) contexts related to the field of study.
- Use and manage bibliography and IT resources related to biotechnology responsibly.
Content
-R+D+I to obtain a product or a microorganism of industrial interest
-The concept of Cellular Factory: Microbial production of enzymes and recombinant drugs
-Experimental design in microbial biotechnology
-Production of recombinant proteins in bacteria, yeast, mammalian cells, insect cells and filamentous fungi
- Recombinant proteins for non-viral gene therapy
- Microbial nanobiotechnology
-Microbiology in different industrial sectors
-Visits to companies, related to the theoretical contents
*Unless the requirements enforced by the health authorities demand a prioritization or reduction of these contents.
Methodology
This module consists of two parts. The first one will be given through lectures and one work in the classroom. The second part will be developed through lectures given by microbiology specialists of different industries and one visit to companies related to microbiology. It is necessary 60 % attendance to the lectures.
*The proposed teaching methodology may experience some modifications depending on the restrictions to face-to-face activities enforced by health authorities.
Activities
| Title | Hours | ECTS | Learning Outcomes |
|---|---|---|---|
| Type: Directed | |||
| Visits to technology centers and companies | 4 | 0.16 | 9 |
| Lectures | 40 | 1.6 | 1, 3, 5, 8, 4, 7 |
| Type: Autonomous | |||
| Personal study | 90 | 3.6 | 1, 3, 5, 8, 4, 6, 9, 7, 10 |
| Preparation of an oral presentation | 25 | 1 | 5, 4, 6, 9, 2, 10 |
| Preparation of group work | 63.75 | 2.55 | 1, 9, 2, 10 |
Assessment
To pass the subject you must obtain a weighted average mark of 5 or higher and a mark of 5 or higher on the individual written tests. If this qualification is not obtained, one or both individual evaluation can be reassessed.
If the written report contains more than 10% of a literal copy of previously published works, the module will not be approved.
We consider that a student will be graded as not evaluable "NO AVALUABLE" if the assessment of all conducted evaluation activities does not allow students to achieve the overall grade of 5 on the assumption that they had obtained the highest grade in all of them.
*Student’s assessment may experience some modifications depending on the restrictions to face-to-face activities enforced by health authorities.
Assessment Activities
| Title | Weighting | Hours | ECTS | Learning Outcomes |
|---|---|---|---|---|
| Evaluation of group assignements: written report | 30 | 0 | 0 | 1, 3, 5, 8, 4, 6, 9, 2, 7, 10 |
| Evaluation of group assignments: oral presentations | 10 | 0.25 | 0.01 | 1, 3, 5, 8, 4, 6, 9, 2, 7 |
| Individual evaluation: multiple choice test | 30 | 1 | 0.04 | 1, 3, 5, 8, 4, 6, 9, 7 |
| Individual evaluation: short questions | 30 | 1 | 0.04 | 1, 3, 5, 8, 4, 6, 9, 7 |
Bibliography
The necessary basic and specific bibliography will be published on the moodle course. The databases will be indicated to obtain the necessary material for the individual works.