Degree | Type | Year | Semester |
---|---|---|---|
4311309 Pharmacology | OT | 0 | 1 |
There are no special prerequisites.
To apply basic pharmacological and methodological knowledge to develop preclinical drug research and interpret the results.
a) Evaluation and validation of a pharmacological target. Molecular screening: automation and high performance. Levels of pharmacological research: computer (in silica), cells, organs, animals, humans. In vitro studies: molecular for the evaluation of targets, cell cultures (biochemical and molecular), isolated organs (physiological, biochemical and molecular). Ex vivo studies. Methodologies used in in vivo studies: conscious animal and anesthetized animal (measurement of blood pressure). Animal models of diseases induced by administration of compounds, by surgical intervention or by genetic manipulation. Methodologies for studies of psychotropic drugs.
b) In silico studies. In vitro studies: physical-chemical characterization (release, dissolution). In vitro studies: metabolism. In vivo studies: handling of animals, choice of species. In vivo studies: design. Microdialysis techniques. Plasma protein binding. Animal / human extrapolation (allometry): data analysis. Toxicokinetics and special pharmacokinetics.
c) Mechanisms of toxicity. In vitro toxicity studies. In vivo toxicity studies: single administration. In vivo toxicity studies: repeated administration. Toxic-anatomopathology. Reproductive toxicology: infertility, teratogenicity (embryotoxicity). Genotoxicity Carcinogenesis Phototoxicity Immunotoxicity Local tolerability Behavior tests
d) Ethics of animal research. Ethical committees BPLs: Good Laboratory Practices. Guidelines for pre-clinical research of Regulatory Agencies. Legislation. Preclinical information for registration. Study of patent situation.
e) Models, development strategies / techniques: empirical, mechanistic. Theory of statistical moments. Convolution / deconvolution: theory and applications. Non-linear adjustment. Population approximation. Sensitivity analysis and biases: strategies and applications.
The final grade is the arithmetic mean of the grades obtained in the subjects that compose it.
Title | Hours | ECTS | Learning Outcomes |
---|---|---|---|
Type: Directed | |||
Classroom practices (PAUL) | 11 | 0.44 | 1, 2, 3, 5, 4, 6, 7 |
Clinical case seminars (SCC) | 4 | 0.16 | 1, 2, 3, 5, 4, 6, 7 |
Master Class (TE) | 50 | 2 | 1, 2, 3, 5, 4, 6, 7 |
Practical Experimental Laboratory (PLAB) | 3 | 0.12 | 1, 2, 3, 5, 4, 6, 7 |
Type: Supervised | |||
Review of papers | 24 | 0.96 | 1, 2, 3, 5, 4, 6, 7 |
Unscheduled tutorials | 3 | 0.12 | 1, 2, 3, 5, 4, 6, 7 |
Type: Autonomous | |||
Study, written works ... | 127 | 5.08 | 1, 2, 3, 5, 4, 6, 7 |
The final grade is the arithmetic mean of the grades obtained in the subjects that compose it.
Title | Weighting | Hours | ECTS | Learning Outcomes |
---|---|---|---|---|
Attendance and participation | 10 % | 0 | 0 | 1, 2, 3, 5, 4, 6, 7 |
Oral presentations | 42,5 % | 2 | 0.08 | 1, 2, 3, 5, 4, 6, 7 |
Short questions exam | 47,5 % | 1 | 0.04 | 1, 2, 3, 5, 4, 6, 7 |
Updated bibliography will be provided for ech subject.
General bibliography:
- T.P. Kenakin. Pharmacology in drug discovery. Ed. Elsevier, 2012
- Guia de desarrollos preclínicos. Genoma España. 10 aniversario (2002-2012)
http://www.agenciasinc.es/Noticias/Genoma-Espana-publica-una-guia-de-desarrollos-preclinicos
- Doménech J, Martínez J, Plá JM. Biofarmacia y Farmacocinética Volumen I: Farmacocinética. 1ª Edición. Madrid: Editorial Síntesis, 1997
- Weisman RS, Smith C, Goldfrank LR. Toxicokinetics. Applying pharmacokinetic principles to the poisoned patient. In: Hoffman RS, Goldfrank LR eds. Contemporary management in critical care. Critical Care Toxicology.New York: Churchill Livingstone, 1991 (vol1; no 3): 21-42.
- Young-Jin S, Shannon M. Pharmacokinetics of Drugs in Overdose. Clinical Pharmacokinetics 1992; 23 (2): 93-105.
- Goodman & Gilman: Las Bases Farmacológicas de la Terapéutica Autor/es :Laurence L. Brunton, John S. Lazo, Keith L. Parker, 2008, 11va edición
- Gary C. Rosenfeld, David S. Loose, Pharmacology, 4th Ed. Lippincott Williams & Wilkins
- Weisman RS, Smith C, Goldfrank LR. Toxicokinetics. Applying pharmacokinetic principles to the poisoned patient. Contemporarymanagement in critical care. 2000.
- Fernández,Velazquez Farmacología básica y clínica, 2008 , 18ª Ed.